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Status |
Public on Sep 11, 2009 |
Title |
Effects of irradiation on mouse lung |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
Total lung RNA from 3 mouse strains after 18Gy thoracic irradiation. Thoracic cavity radiotherapy is limited by the development of alveolitis and fibrosis in susceptible patients. To define the response to 18 Gy pulmonary irradiation in mice, at the expression level, and to identify pathways which may influence the alveolitis and fibrosis phenotypes expression profiling was completed. Male mice of three strains, A/J (late alveolitis response), C3H/HeJ (C3H, early alveolitis response) and C57BL/6J (B6, fibrosis response) were exposed to thoracic radiation, euthanised when moribund and lung tissue gene expression was assessed with microarrays.
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Overall design |
treated vs. control in 3 strains
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Contributor(s) |
Haston CK |
Citation missing |
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Submission date |
Feb 07, 2005 |
Last update date |
Feb 11, 2019 |
Contact name |
Christina Kathleen Haston |
E-mail(s) |
christina.haston@mcgill.ca
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Phone |
514-398-3864 089714
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Organization name |
McGill University
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Department |
Medicine
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Street address |
3626 St. Urbain
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City |
Montreal |
State/province |
QC |
ZIP/Postal code |
H2X 2P2 |
Country |
Canada |
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Platforms (1) |
GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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Samples (18)
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Relations |
BioProject |
PRJNA91351 |