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Series GSE22553 Query DataSets for GSE22553
Status Public on Jun 25, 2010
Title Cardiac Effects of Rosiglitazone in Male Wistar Rats
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary Rosiglitazone, a peroxisome proliferator-activated receptor g (PPARg) agonist of the thiazolidinedione class, is a major insulin-sensitizing drug widely used to treat type-2 diabetes. Rosiglitazone causes myocardial hypertrophy in rodents and increases the risk of cardiac events in man. To better characterize its cardiac effects, male Wistar rats were orally administered 0, 10 or 80 mg/kg/day rosiglitazone.
 
Overall design Male Wistar rats were orally administered 0, 10 or 80 mg/kg/day rosiglitazone once per day for 14 days. Samples were obtained 6, 24, 168 or 336 hours after the final treatment.
 
Contributor(s) Mikaelian I, Kanwal C
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Jun 24, 2010
Last update date Jul 31, 2017
Contact name Mary Simcox
E-mail(s) msimcox@formatherapeutics.com
Phone 857-209-2853
Organization name Forma Therapeutics
Street address 500 Arsenal St
City Watertown
State/province MA
ZIP/Postal code 02472
Country USA
 
Platforms (1)
GPL1355 [Rat230_2] Affymetrix Rat Genome 230 2.0 Array
Samples (62)
GSM559729 CardiacMuscle_Vehicle_6hrs_rep1
GSM559730 CardiacMuscle_Vehicle_6hrs_rep3
GSM559731 CardiacMuscle_Vehicle_6hrs_rep5
Relations
BioProject PRJNA128455

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE22553_RAW.tar 179.0 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file
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