|
| Status |
Public on Jan 01, 2011 |
| Title |
Genome-wide maps of Sin3A and Sin3B binding in C2C12 myoblasts and differentiated myotubes |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Sin3A and Sin3B bind to distinct and overlapping target sites. Sin3 proteins bind to distinct sites in cycling myoblasts whereas there is a converge of Sin3A and Sin3B proteins to sites in differentiated myotubes. We identified a subset of Sin3 target genes involved in muscle differentiation and physiology and showed that conditional ablation of Sin3 proteins in vivo in mouse results in sarcomere defects
|
| |
|
| Overall design |
Examination of Sin3A and Sin3B binding during myogenesis
|
| |
|
| Contributor(s) |
van Oevelen C, Bowman C, Asp P, Cheng J, Parisi F, Micsinai M, Kluger Y, Dynlacht B |
| Citation(s) |
20956564 |
| Submission date |
Jun 24, 2010 |
| Last update date |
May 15, 2019 |
| Contact name |
Brian Dynlacht |
| E-mail(s) |
Brian.Dynlacht@nyumc.org
|
| Phone |
212-263-6162
|
| Organization name |
NYU Medical Center
|
| Department |
Cancer Institute
|
| Lab |
Dynlacht
|
| Street address |
550 1 Av
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10016 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL9185 |
Illumina Genome Analyzer (Mus musculus) |
|
| Samples (14)
|
|
| Relations |
| SRA |
SRP002800 |
| BioProject |
PRJNA128453 |
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