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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 31, 2010 |
| Title |
Changes in Hepatic Gene Expression upon Oral Administration of Taurine-Conjugated Ursodeoxycholic Acid in ob/ob Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
We examined the effect of oral TUDCA treatment on hepatic steatosis and associated changes in hepatic gene expression in ob/ob mice.
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| Overall design |
We administered TUDCA to ob/ob mice at a dose of 500 mg/kg twice a day by gastric gavage for 3 weeks. Body weight, glucose homeostasis, endoplasmic reticulum (ER) stress, and hepatic gene expression were examined in comparison with control ob/ob mice and normal littermate C57BL/6J mice.
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| Contributor(s) |
Yang J, Kim JT, Jeon J, Park HS, Kang GH, Park KS, Lee HK, Kim S, Cho YM |
| Citation(s) |
21079772 |
| Submission date |
Jun 29, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Jae-Seong Yang |
| E-mail(s) |
destine@postech.ac.kr
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| Organization name |
Pohang University of Science and Technology
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| Department |
School of Interdisciplinary Bioscience and Bioengineering
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| Lab |
Structural Bioinformatics Laboratory
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| Street address |
San 31 Hyoja-dong
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| City |
Pohang |
| ZIP/Postal code |
790-784 |
| Country |
South Korea |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA128347 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE22608_RAW.tar |
36.7 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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