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Series GSE22616 Query DataSets for GSE22616
Status Public on Jun 30, 2010
Title Gene expression in the Efferent duct, Epididymis, and Vas deferens during Embryonic Development
Organism Mus musculus
Experiment type Expression profiling by array
Summary The tissues of the male reproductive tract are characterized by distinct morphologies, ranging from highly coiled to un-coiled. Global gene expression profiles of the efferent ducts, epididymis, and vas deferens were generated from embryonic day 14.5 to postnatal day 1, the period when gross morphological changes are initiated and tissue-specific morphologies emerge. Expression profiles of homeobox genes, as potential regionalization factors, were examined. Tissue transcriptome comparison identified two expression profiles of interest: genes similar between the epididymis and vas deferens early in development but dissimilar later and genes dissimilar between the epididymis and efferent duct early but similar later. Ontology analysis demonstrated cell adhesion-associated genes to be highly enriched in both comparisons. This work identified several potential regulators of cell adhesion along the tract and indicates cell adhesion may be modulated in a tissue-specific manner, playing an important role in the establishment of each tissue’s final morphology.
Overall design Efferent duct, epididymis, and vas deferens samples at E14.5, E16.5, E18.5, and P1 in duplicate
Developmental time course, tissue to tissue comparison, microarray study
Contributor(s) Snyder E
Citation(s) 20652947
Submission date Jun 29, 2010
Last update date Feb 11, 2019
Contact name Elizabeth M Snyder
Organization name Washington State University
Department School of Molecular Biosciences
Lab Griswold
Street address PO Box 647520
City Pullman
State/province WA
ZIP/Postal code 99164-7520
Country USA
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (24)
GSM560923 Efferent duct_E14.5_rep2
GSM560924 Efferent duct_E14.5_rep1
GSM560925 Efferent duct_E16.5_rep2
BioProject PRJNA128521

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE22616_RAW.tar 88.9 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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