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| Status |
Public on Oct 06, 2005 |
| Title |
Downstream targets of Pax6 in the early developing rat brains |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
Pax6 is a transcription factor that is expressed in neuroepithelial cells from the initial stage of brain development. Region specific expression of Pax6 plays pivotal roles in the developing CNS, including brain patterning, neuronal specification, neuronal migration, and axonal projection. Regarding neurogenesis, Pax6 multiply works either as to promote neuronal differentiation or cell proliferation in a highly context-dependent manner. However, no Pax6 target gene is identified as to promote proliferation and/or inhibit differentiation of neuroepithelial cells. Here, we performed comparative analysis using the Affymetrix U34A array to identify genes that are differentially expressed in the early stage of wild-type and Pax6 homozygous mutant rat (rSey2/rSey2) brains.
Keywords = Pax6 transcription factor
Keywords = rat
Keywords = forebrain and hindbrain regions of the wild-type or Pax6 homozygous embryos
Keywords = up-or down-regulated genes
Keywords: ordered
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| Contributor(s) |
Arai Y, Funatsu N, Numayama-Tsuruta K, Nomura T, Nakamura S, Osumi N |
| Citation(s) |
16237179 |
| Submission date |
Feb 14, 2005 |
| Last update date |
Feb 21, 2017 |
| Contact name |
Yoko Arai |
| E-mail(s) |
yarai@mail.tains.tohoku.ac.jp, osumi@mail.tains.tohoku.ac.jp
|
| Phone |
+81-22-717-8203
|
| Fax |
+81-22-717-8205
|
| URL |
http://www.med.tohoku.ac.jp/~dev_neurobio/index.html
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| Organization name |
Tohoku Univ. Sch. of Med
|
| Department |
Div. Devel. Neurosci
|
| Street address |
2-1, Seiryo-machi, Aoba-ku,
|
| City |
Sendai |
| State/province |
Miyagi |
| ZIP/Postal code |
980-8575 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL85 |
[RG_U34A] Affymetrix Rat Genome U34 Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA91393 |
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