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| Status |
Public on Aug 26, 2011 |
| Title |
Comparison of enchondromas with controls (growth plate and cartilage) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Ollier disease is a rare, non-hereditary disorder which is characterized by the presence of multiple enchondromas (EC), benign cartilaginous neoplasms arising within the medulla of the bone, with an asymmetric distribution. The risk of malignant transformation towards central chondrosarcoma (CS) is increased up to 35%. The etiology of Ollier disease is unknown. We therefore undertook genome-wide expression profiling using Illumina Beadarray v3.0 for 7 enchondromas of 6 patients and compared them with controls in order to find differentially expressed genes in these benign tumors.
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| Overall design |
The goal of this study was to find differentially expressed genes between enchondromas, a benign cartilage forming tumor occuring in the metaphyses of bone, and controls. We have used samples of normal growth plate and articular cartilage as the controls. Seven enchondromas were compared to two growth plate and four cartilage samples.
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| Contributor(s) |
Pansuriya TC |
| Citation(s) |
21235737 |
| Submission date |
Jul 09, 2010 |
| Last update date |
Feb 18, 2019 |
| Contact name |
Twinkal Chandubhai Pansuriya |
| E-mail(s) |
t.c.pansuriya@lumc.nl
|
| Phone |
0031715266528
|
| Organization name |
LUMC
|
| Department |
Pathology
|
| Street address |
Albinusdreef 2
|
| City |
Leiden |
| State/province |
Zuid-Holland |
| ZIP/Postal code |
2333ZA |
| Country |
Netherlands |
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| Platforms (1) |
| GPL6884 |
Illumina HumanWG-6 v3.0 expression beadchip |
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| Samples (13)
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| This SubSeries is part of SuperSeries: |
| GSE22965 |
Genome-wide analysis of Ollier disease: Is it all in the genes? |
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| Relations |
| BioProject |
PRJNA129133 |
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