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Series GSE23036 Query DataSets for GSE23036
Status Public on May 31, 2011
Title Gene expression signatures and molecular markers associated with clinical outcome in locally advanced head and neck carcinoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The purpose of our study was to identify expression signatures and molecular markers associated with tumor recurrence and survival in patients with locally advanced head and neck squamous cell carcinoma (HNSCC).
We studied the expression profile of 63 pre-treatment tumor biopsies obtained from locally advanced HNSCCs treated with standard treatments. Cluster analysis identified three tumor subtypes associated with significant differences in local recurrence-free survival (LRFS), progression free-survival (PFS) and overall survival (OS). Tumor subtype 1, associated with short LRFS, PFS and OS, showed features of epithelial-mesenchymal transition and undifferentiation. It also overexpressed genes involved in cell adhesion, NF-κB and integrin signalling. Tumor subtype 3, associated with longer LRFS, PFS and OS, showed a high degree of differentiation and overexpressed genes located in chromosomal regions 19q13 and 1q21. Tumor subtype 2, which had a clinical outcome intermediate between subtype 1 and subtype 3, overexpressed genes involved in branching morphogenesis. Receiver Operating Characteristic (ROC) analysis identified a subset of genes associated with local recurrence and survival. We validated the association between gene cluster classification and patient survival using two HNSCC data sets obtained from two independent patient cohorts. Finally, using the gene expression profile of the pre-treatment tumor biopsy, we generated a gene expression signature that could predict survival in locally advanced patients.
 
Overall design Sixty three pretreatment HNSCC biopsies and five normal mucosas were assayed using the Affymetrix HG-U133A2.0 array.
 
Contributor(s) Pavón M, Parreño M, Tellez M, Sancho FJ, López M, Céspedes M, Casanova I, López-Pousa A, Mangues M, Quer M, Barnadas A, León X, Mangues R
Citation(s) 22696598
Submission date Jul 20, 2010
Last update date Dec 06, 2018
Contact name MIGUEL ANGEL PAVON
E-mail(s) mpavon@santpau.cat
Organization name HOSPITAL DE LA SANTA CREU I SANT PAU
Department INSTITUT INVESTIGACIÓ BIOMÉDICA SANT PAU
Lab GRUP D' ONCOGÈNESI I ANTITUMORALS
Street address Sant Antoni Maria Claret, 167
City Barcelona
State/province Barcelona
ZIP/Postal code 08173
Country Spain
 
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (68)
GSM568517 pre-treatment tumor biopsy HPS_200
GSM568518 pre-treatment tumor biopsy HSP_202
GSM568519 pre-treatment tumor biopsy HSP_207
Relations
BioProject PRJNA131171

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23036_RAW.tar 123.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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