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Series GSE23160 Query DataSets for GSE23160
Status Public on Jan 10, 2011
Title Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model.
Organism Mus musculus
Experiment type Expression profiling by array
Summary Ischemic stroke triggers severe focal hypoperfusion accompanied with deprivation of oxygen and glucose to the cerebral tissue, together with loss of ATP, depolorization of neurons, elevated extracellular potassium concentration, and subsequently leads to excitotoxicity as well as increased oxidative stress promoting microvascular injury, blood-brain-barrier deregulation, post-ischemic inflammation and eventually the consequential neurological deficit. Although reperfusion of ischemic brain tissue is critical for restoring normal function, it can paradoxically result in secondary damage, called ischemia/reperfusion (I/R) injury.
 
Overall design Microarray analysis was performed on the right striatum and cortex (corresponded to infarct area) of post-I/R injured brain tissues of wild-type (WT-MCAO) using Illumina mouse Ref8 V2 genechips. Suture-induced middle cerebral artery occlusion was induced for 2h followed by reperfusion, with tissue extraction taking place 2h, 8h and 24h post-reperfusion (n=4 respectively). Sham controls were included in this study too (n=4 respectively).
 
Contributor(s) Cheung NS, Chen MJ, Crack P, Manikandan J
Citation(s) 21193029
Submission date Jul 26, 2010
Last update date Jun 14, 2018
Contact name Minghui Jessica Chen
Organization name Menzies Research Institute
Department Neuroscience group
Lab A/P Steve Cheung
Street address Menzies Research Institute, University of Tasmania, Private Bag 24
City Hobart
State/province Tasmania
ZIP/Postal code 7001
Country Australia
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (32)
GSM570185 Cortex-Sham-Rep1_WT-MCAO
GSM570186 Cortex-Sham-Rep2_WT-MCAO
GSM570187 Cortex-Sham-Rep3_WT-MCAO
This SubSeries is part of SuperSeries:
GSE23163 Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo mouse model.
Relations
BioProject PRJNA133269

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23160_RAW.tar 3.1 Mb (http)(custom) TAR
GSE23160_WT_MCAOCortex_Sample_Gene_Profile.txt.gz 3.1 Mb (ftp)(http) TXT
GSE23160_WT_MCAOStriata_Sample_Probe_Profile.txt.gz 4.7 Mb (ftp)(http) TXT
GSE23160_non_normalized.txt.gz 2.3 Mb (ftp)(http) TXT
Processed data included within Sample table
Raw data are available on Series record

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