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Status |
Public on May 09, 2011 |
Title |
Gene expression profiles of endometriosis |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Endometriosis is a common disease seen by gynecologists. Clinical features involve pelvic pain and unexplained infertility. Although endometriosis is pathologically characterized by endometrial tissue outside the normal uterine location, endometriosis is otherwise not easily explained. Endometriomas, endometriotic cysts of the ovary, typically cause pain and distortion of pelvic anatomy. To begin to understand the pathogenesis of endometriomas, we carried out transcriptome:microRNAome analysis of endometriomas and eutopic endometrium, using gene expression arrays and next generation small RNA sequencing technology. Keywords: two group comparison
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Overall design |
Patients undergoing surgery for endometriomas, suspected endometriosis, pelvic pain, abnormal uterine bleeding, pelvic organ prolapse, or uterine leiomyomas were approached for participation. After informed consent, the patients underwent scheduled surgical procedure. Tissues were collected either as cyst wall of endometrioma or endometrial curettage of hysterectomy specimen and placed directly into RNALater (Ambion, Austin, TX) and eventually frozen at -80˚C. Samples were designated as endometriomas or non-endometriosis control endometrium based on surgical pathology reports. Total RNA was isolated from frozen tissue. High quality RNA was subjected to Illumina’s Human WG-6 version 2.0 BeadChips (Illumina). . *** This Series represents the transcriptome component of the study. ***
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Contributor(s) |
Creighton C, Matzuk M, Hawkins S |
Citation(s) |
21436257 |
Submission date |
Jul 30, 2010 |
Last update date |
Feb 15, 2013 |
Contact name |
Chad Creighton |
E-mail(s) |
creighto@bcm.tmc.edu
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Organization name |
Baylor College of Medicine
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Department |
Biostatistics, Ducan Cancer Center
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Street address |
One Baylor Plaza, Mail Stop: BCM305
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City |
Houston |
State/province |
TX |
ZIP/Postal code |
77030 |
Country |
USA |
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Platforms (1) |
GPL6102 |
Illumina human-6 v2.0 expression beadchip |
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Samples (19)
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GSM572750 |
endometrioma, patient 7 |
GSM572751 |
endometrioma, patient 9 |
GSM572752 |
control endometrium, patient 12 |
GSM572753 |
control endometrium, patient 18 |
GSM572754 |
control endometrium, patient 20 |
GSM572755 |
control endometrium, patient 24 |
GSM572756 |
control endometrium, patient 25 |
GSM572757 |
control endometrium, patient 4 |
GSM572758 |
endometrioma, patient M2 |
GSM572759 |
endometrioma, patient M3 |
GSM572760 |
endometrioma, patient M4 |
GSM572761 |
control endometrium, patient 1 |
GSM572762 |
control endometrium, patient 3 |
GSM572763 |
endometrioma, patient M1 |
GSM572764 |
control endometrium, patient 32 |
GSM572765 |
endometrioma, patient 14 |
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Relations |
BioProject |
PRJNA131475 |
Supplementary file |
Size |
Download |
File type/resource |
GSE23339_RAW.tar |
18.5 Mb |
(http)(custom) |
TAR (of TXT) |
Processed data included within Sample table |
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