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GEO help: Mouse over screen elements for information. |
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Status |
Public on Feb 08, 2011 |
Title |
Gene Expression Profiling In Murine Corneal Neovascularization Models |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
In order to find out the vital genes during the corneal neovascularization (CNV), we set up two CNV models, one being induced by suture placement and the other by alkali burn to the corneal center. Young adult Balb/c and C57BL/6 were used. The corneas were checked daily for CNV development and some of the corneas were removed at two pre-determined time points for RNA extraction. Preliminary experiment indicated slightly different dynamics in suture- or chemical burn-induced CNV. Vigorous growth appeared at day 5 and day 6 in S-CNV and CB-CNV, and reached maximum length around day 10 and day 14, respectively, in S-CNV and CB-CNV. To check whether genetic MHC background has any effect on development of CNV, we compared CB-CNV in Balb/c and C57BL/6 mice at day 6.
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Overall design |
Corneas from Balb/c mice were isolated 5 and 10 days after suture-induced CNV, and 6 and 14 days after chemical burn-induced CNV. Corneas from C57BL/6 mice were isolated 6 days after chemical burn-induced CNV. Each time point had two or three biological replications.
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Contributor(s) |
Wang Y, Wang C, Jia C, Ren S, Yang L |
Citation(s) |
20596249, 21139687, 21921991, 28847716, 24790856 |
Submission date |
Jul 30, 2010 |
Last update date |
Aug 22, 2019 |
Contact name |
Yiqiang Wang |
E-mail(s) |
yiqiangwang99@hotmail.com
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Phone |
86-512-67780780
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Organization name |
Xiamen University
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Street address |
2000 East Xiangan Road
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City |
Xiamen |
ZIP/Postal code |
361101 |
Country |
China |
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Platforms (1) |
GPL10745 |
CapitalBio 36K Mouse Genome Array |
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Samples (12)
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GSM572955 |
Suture-induced CNV After Injury 5 Day, Replication 1 |
GSM572956 |
Suture-induced CNV After Injury 5 Day, Replication 2 |
GSM572957 |
Suture-induced CNV After Injury 5 Day, Replication 3 |
GSM572958 |
Suture-induced CNV After Injury 10 Day, Replication 1 |
GSM572959 |
Suture-induced CNV After Injury 10 Day, Replication 2 |
GSM572960 |
Chemical burn-induced CNV After Injury 6 Day, Replication 1 |
GSM572961 |
Chemical burn-induced CNV After Injury 6 Day, Replication 2 |
GSM572962 |
Chemical burn-induced CNV After Injury 6 Day, Replication 3 |
GSM572963 |
Chemical burn-induced CNV After Injury 14 Day, Replication 1 |
GSM572964 |
Chemical burn-induced CNV After Injury 14 Day, Replication 2 |
GSM572965 |
Chemical burn-induced CNV After Injury 6 Day, Replication 1 (C57BL/6) |
GSM572966 |
Chemical burn-induced CNV After Injury 6 Day, Replication 2 (C57BL/6) |
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Relations |
BioProject |
PRJNA131455 |
Supplementary file |
Size |
Download |
File type/resource |
GSE23347_RAW.tar |
26.9 Mb |
(http)(custom) |
TAR (of LSR) |
Processed data included within Sample table |
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