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Series GSE23394 Query DataSets for GSE23394
Status Public on Jul 23, 2013
Title Expression data from human NHL cell lines treated with agonistic antibodies
Organism Homo sapiens
Experiment type Expression profiling by array
Summary CD20 is a clinically validated target for Non-Hodgkin’s lymphomas and autoimmune diseases. Interactions of CD20 with the B cell receptor (BCR) and components of the BCR signaling cascade have been reported. In this study we show that antibodies against CD20 or activation of the BCR by specific antibodies induce very similar expression patterns of up- or down-regulated genes in NHL cell lines indicating that CD20 may play a role in BCR signaling and vice versa.
We used microarray data to show that antibodies against CD20 or activation of the BCR by specific antibodies induce very similar expression patterns of up- or down-regulated genes in NHL cell lines indicating that CD20 may play a role in BCR signaling and vice versa.
 
Overall design Four different cell lines were treated with various antibodies for 4h (3 replicates per treatment), all in all 96 arrays were analysed for 32 samples. Changes were calculated relative to control/reference experiments. Expression patterns of each treatment were compared to determine overlaps.
 
Contributor(s) Franke A, Klein C, Niederfellner G, Burtscher H
Citation(s) 21364752
Submission date Aug 03, 2010
Last update date Mar 25, 2019
Contact name Helmut Burtscher
E-mail(s) helmut.burtscher@roche.com
Organization name Roche Pharma
Street address Nonnenwald 2
City Penzberg
ZIP/Postal code 82377
Country Germany
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (96)
GSM573702 SUDHL4-Control-4h-rep1
GSM573703 SUDHL4-Control-4h-rep2
GSM573704 SUDHL4-Control-4h-rep3
Relations
BioProject PRJNA131291

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23394_Matrix-triplicates.xls.gz 14.4 Mb (ftp)(http) XLS
GSE23394_RAW.tar 492.9 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data are available on Series record

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