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Series GSE23426 Query DataSets for GSE23426
Status Public on Feb 17, 2011
Title Analysis of the miRNA profile associated with c-Src-mediated transformation
Organism Mus musculus
Experiment type Non-coding RNA profiling by array
Summary To address the molecular mechanisms underlying c-Src-mediated tumor progression, we previously developed a model system using Csk-deficient fibroblasts that can be transformed by wild-type c-Src. In this study, we applied this system for the analysis of the potential contribution of miRNA to c-Src-mediated transformation. Pair-wise significance analysis of the microarray indicated that seven miR genes were significantly upregulated and six miRNA genes were downregulated in c-Src-transformed cells with a P value below 0.01 and with a fold change over 2.0.
 
Overall design Csk-/- mouse embryonic fibroblasts (Csk-/- MEFs) were transfected with empty vector, c-Src, Csk/c-Src, or Csk. Each sample was run in duplicate.
 
Contributor(s) Oneyama C, Okuzaki D, Okada M
Citation(s) 21383697
Submission date Aug 04, 2010
Last update date Mar 22, 2012
Contact name Daisuke Okuzaki
E-mail(s) dokuzaki@biken.osaka-u.ac.jp
Phone +81-6-6879-4935
Organization name Osaka univ.
Department Immunology Frontier Research Center
Lab Human Immunology (Single Cell Genomics)
Street address Yamadaoka 3-1
City Suita
State/province Osaka
ZIP/Postal code 565-0871
Country Japan
 
Platforms (1)
GPL9756 Agilent-021828 Unrestricted Mouse miRNA Microarray (miRNA_105_Dec08)
Samples (8)
GSM575141 CskKO/mock_biological rep1
GSM575142 CskKO/Src_biological rep1
GSM575143 CskKO/Csk+Src_biological rep1
Relations
BioProject PRJNA131047

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23426_RAW.tar 13.6 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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