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Series GSE23512 Query DataSets for GSE23512
Status Public on Nov 15, 2010
Title Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise.
Organism Mus musculus
Experiment type Expression profiling by array
Summary Inbred individuals reared in controlled environments display considerable variance in many complex traits. The underlying cause of this variability has been an enigma, hence the term intangible variation. Here we show that two modifiers of epigenetic gene silencing play a critical role in the process. Inbred mice heterozygous for a null mutation in DNA methyltransferase 3a (Dnmt3a) or tripartite motif protein 28 (Trim28), show greater coefficients of variance in body weight than their wildtype littermates. Inbred mice carrying a mutation in Trim28 develop metabolic syndrome and abnormal behaviour with incomplete penetrance. These studies provide a molecular explanation of developmental noise in whole organisms and suggest that faithful epigenetic control of transcription is central to suppressing deleterious levels of phenotypic variation. These findings have broad implications for understanding the mechanisms underlying sporadic and complex disease in humans.
 
Overall design Liver gene expression in Trim28MommeD9 heterozygotes compared to wildtype littermates.
 
Contributor(s) Chong S
Citation(s) 21092094
Submission date Aug 09, 2010
Last update date Jun 14, 2018
Contact name Suyinn Chong
Organization name Queensland Institute of Medical Research
Department Division of Genetics and Population Health
Lab Epigenetics Laboratory
Street address 300 Herston Rd
City Herston
State/province Queensland
ZIP/Postal code 4006
Country Australia
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (16)
GSM575874 liver_Trim28MommeD9/+ _rep1
GSM575875 liver_Trim28MommeD9/+ _rep2
GSM575876 liver_Trim28MommeD9/+ _rep3
Relations
BioProject PRJNA131085

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE23512_RAW.tar 3.1 Mb (http)(custom) TAR
GSE23512_non-normalized.txt.gz 2.6 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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