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| Status |
Public on Jan 30, 2012 |
| Title |
Gene expression profiling of asbestos-related lung squamous cell carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To identify gene expression biomarkers associate with asbestos-related lung squamous cell carcinoma, we analyzed gene expression profiles for a total of 56 lung squamous cell carcinomas using 44K Illumina Gene Expression microarrays. Twenty-six cases had lung asbestos body counts above levels associated with urban dwelling (ARLC-SCC: asbestos-related lung cancer-squamous cell carcinoma) and 30 cases had no lung asbestos bodies (NARLC-SCC: non-asbestos related lung cancer- squamous cell carcinoma). Genes differentially expressed between ARLC-SCC and NARLC-SCC were identified on fold change and P-value, and then prioritised using gene ontology.
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| Overall design |
Total RNA was obtained from fresh frozen lung tumour tissue and stratified by asbestos phenotype. Gene expression profiling was performed to identify differences in the gene profiles of asbestos-related and non-asbestos related lung squamous cell carcinomas.
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| Contributor(s) |
Wright CM, Savarimuthu-Francis SM, Tan ME, Hayward NK, Martins MU, Yang IA, Bowman RV, Fong KM |
| Citation(s) |
22514692 |
| Submission date |
Aug 26, 2010 |
| Last update date |
Aug 16, 2018 |
| Contact name |
Casey M Wright |
| E-mail(s) |
casey.wright@uqconnect.edu.au
|
| Phone |
+61 2 97679818
|
| Organization name |
ADRI
|
| Street address |
Gate 3, Hospital Road
|
| City |
Concord |
| State/province |
NSW |
| ZIP/Postal code |
2139 |
| Country |
Australia |
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| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
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| Samples (56)
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| Relations |
| BioProject |
PRJNA130571 |
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