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| Status |
Public on Oct 31, 2010 |
| Title |
Histone H3K27ac separates active from poised enhancers and predicts developmental state (gene expression data) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome. These regulatory events at enhancers contribute to the specific gene expression programs that determine cell state and the potential for differentiation into new cell types. While enhancer elements are known to be associated with certain histone modifications, and transcription factors, the relationship of these modifications to gene expression and developmental state has not been clearly defined. Here we interrogate the epigenetic landscape of enhancer elements in embryonic stem cells and several adult tissues in the mouse. We find that histone H3K27ac distinguishes active enhancers from inactive/poised enhancer elements, thus providing clues to current cell state and further developmental potential.
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| Overall design |
Gene expression profiling was performed in mouse ES, NPC, liver, and pro-B
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| Contributor(s) |
Creyghton MP, Cheng AW, Jaenisch R |
| Citation(s) |
21106759 |
| Submission date |
Aug 31, 2010 |
| Last update date |
May 10, 2018 |
| Contact name |
Menno P Creyghton |
| E-mail(s) |
m.creyghton@hubrecht.eu
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| Organization name |
Hubrecht Institute
|
| Lab |
Creyghton
|
| Street address |
Uppsalalaan 8
|
| City |
Utrecht |
| ZIP/Postal code |
3584 CT |
| Country |
Netherlands |
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| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE24165 |
Histone H3K27ac separates active from poised enhancers and predicts developmental state |
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| Relations |
| BioProject |
PRJNA133189 |
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