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| Status |
Public on May 27, 2014 |
| Title |
Transgenic SCLC induced by E6/E7 oncoproteins vs normal controls |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
The human papillomavirus virus (HPV) is a proven cause of most human cervical cancers, and might have a role in other malignancies including vulva, skin, oesophagus, head and neck cancer. HPV has also been speculated to have a role in the pathogenesis of lung cancer. To validate the hypothesis of HPV involvement in small cell lung cancer pathogenesis we performed gene expression profile of transgenic mouse model of SCLC induced by HPV-16 E6/E7 oncoproteins.
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| Overall design |
Gene expression profile of SCLC has been performed using Agilent whole mouse genome (4x44k) representing ~ 41000 genes and mouse transcripts. Samples were obtained from two HPV16-E6/E7 transgenic mouse model and from littermate’s normal lung.
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| |
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| Contributor(s) |
Martinelli R, Buonomo T |
| Citation(s) |
21205295 |
| Submission date |
Sep 03, 2010 |
| Last update date |
May 10, 2018 |
| Contact name |
Rosanna Martinelli |
| E-mail(s) |
rmartinelli@unisa.it
|
| Phone |
+39 089965040
|
| Organization name |
Salerno University
|
| Department |
Medicine and Surgery
|
| Street address |
Via Allende
|
| City |
Baronissi (SA) |
| ZIP/Postal code |
84081 |
| Country |
Italy |
| |
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| Platforms (1) |
| GPL4134 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Feature Number version) |
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| Samples (4)
|
| GSM590288 |
Small cell lung cancer from transgenic mouse CK5-PAP-2303.1, Biological replicate 1 |
| GSM590289 |
Small cell lung cancer from transgenic mouse CK5-PAP-2303.2, Biological replicate 2 |
| GSM590290 |
Small cell lung cancer from transgenic mouse CK5-PAP-2303.1, Technical Replicate of Biological Replicate 1 |
| GSM590291 |
Small cell lung cancer from transgenic mouse CK5-PAP-2303.2, Technical Replicate of Biological Replicate 2 |
|
| Relations |
| BioProject |
PRJNA130389 |
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