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| Status |
Public on Sep 14, 2010 |
| Title |
Comparison of gene expression profiles in chromate transformed BEAS-2B cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
We established chromate transformed cell lines by chronic exposure of normal human bronchial epithelial BEAS-2B cells to low doses of hexavalent chromium followed by anchorage-independent growth. The gene expression profiles were analyzed in the established cell lines.
The gene expression profiles from six chromate transformed cell lines were remarkably similar to each other yet differed significantly from that of either control cell line or normal Beas-2B cells. A total of 409 differentially expressed genes were identified in chromate transformed cells compared to control cells.
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| Overall design |
We analyzed gene expression profiles from 10 cell lines ( six chromated transformed cells lines, three control cell lines, and parental BEAS-2B cells) using Affymetrix Human Gene 1.0 ST array. No techinical replicates were performed.
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| Contributor(s) |
Sun H, Clancy HA, Kluz T, Zavadil J, Costa M |
| Citation(s) |
21437242 |
| Submission date |
Sep 08, 2010 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Hong Sun |
| Organization name |
NYU School of Medicine
|
| Department |
Medicine
|
| Lab |
Sun Lab
|
| Street address |
341 East 25 Street
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10010 |
| Country |
USA |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (10)
|
| GSM591433 |
chromium transformed cell line (small colony) #1 |
| GSM591434 |
chromium transformed cell line (small colony) #2 |
| GSM591435 |
chromium transformed cell line (small colony) #3 |
| GSM591436 |
chromium transformed cell line (large colony) #1 |
| GSM591437 |
chromium transformed cell line (large colony) #2 |
| GSM591438 |
chromium transformed cell line (large colony) #3 |
| GSM591439 |
parental Beas-2B cells |
|
| Relations |
| BioProject |
PRJNA130271 |
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