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Series GSE24187 Query DataSets for GSE24187
Status Public on Sep 05, 2011
Title Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Affymetrix platform]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary With particular emphasis on interactions between cholesterol homeostasis and drug metabolism we investigate the transcriptome of human primary hepatocytes treated by two commonly prescribed cholesterol lowering drugs atorvastatin and rosuvastatin and by rifampicin that serves as an outgroup as well as a model substance for induction of nuclear receptor PXR.
Expression profiling with Affymetrix whole genome arrays shows that statins induce extensive transcriptome changes.
 
Overall design 7 condition experiment: 3 treatments (atorvastatin, rifampicin, rosuvastatin), each measured at 2 time points (24 and 48 hours), and untreated cells. 4-6 biological replicates for each condition.
 
Contributor(s) Hafner M, Juvan P, Režen T, Rozman D
Citation(s) 21869732
Submission date Sep 17, 2010
Last update date Mar 25, 2019
Contact name Peter Juvan
Phone +386 1 543 7595
Organization name Faculty of Medicine, University of Ljubljana
Department Institute of Biochemistry
Lab Center for Functional Genomics and Bio-Chips
Street address Zaloska 4
City Ljubljana
ZIP/Postal code SI-1000
Country Slovenia
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (40)
GSM595029 Atorvastatin 24h donor 089 [Affy]
GSM595030 Atorvastatin 24h donor 114 [Affy]
GSM595031 Atorvastatin 24h donor 129 [Affy]
This SubSeries is part of SuperSeries:
GSE24188 Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome
Relations
BioProject PRJNA133701

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE24187_RAW.tar 186.2 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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