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| Status |
Public on Oct 19, 2010 |
| Title |
Gene expression from beagle dog mandible |
| Organism |
Canis lupus familiaris |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, beta-TCP was implanted in dog mandibles, after which the gene expression profiles and signaling pathways were monitored using microarray and Ingenuity Pathways Analysis (IPA). Following the extraction of premolars and subsequent bone healing, beta‑TCP was implanted into the artificial osseous defect. Total RNA was isolated from bone tissues and gene expression profiles were examined using microarray analysis.
We used microarrays to detail the global programme of gene expression and identified distinct classes of up- and down- regulated genes during this process.
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| Overall design |
Waiting 3 months healing after tooth extraction from beagle dog mandibles, we drilled the holes in the dog mandibles, and implanted without and with beta-TCP. And these dog mandibles were selected for RNA extraction and hybridization on Affymetrix microarrays. After implanting beta-TCP in the dog mandibles 4, 7, 14 days, we selected sample at 3 time points: Control_4d, beta-TCP_4d, Control_7d, beta-TCP_7d, Control_14d, beta-TCP_14d.
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| Contributor(s) |
Zhao J, Watanabe T, Bhawal UK, Kubota E, Abiko Y |
| Citation(s) |
21134491 |
| Submission date |
Oct 18, 2010 |
| Last update date |
Mar 22, 2012 |
| Contact name |
Jian Zhao |
| E-mail(s) |
spacy0525@yahoo.com.cn
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| Organization name |
Nihon University School of Dentistry at Matsudo
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| Street address |
2-870-1 Sakaecho-nishi
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| City |
Matsdo |
| ZIP/Postal code |
271-8587 |
| Country |
Japan |
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| Platforms (1) |
| GPL3738 |
[Canine_2] Affymetrix Canine Genome 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA132155 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE24756_RAW.tar |
19.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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