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| Status |
Public on Oct 22, 2010 |
| Title |
Transcriptional changes in Sohlh1 knockout and Sohlh2 knockout mouse newborn ovaries |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Sohlh1 and Sohlh2 are germ cell-specific basic helix-loop-helix transcription factors critical in early folliculogenesis. We discovered that Sohlh1 and Sohlh2 knockout females lose oocytes after birth and few remains by postnatal day 14. Here, we show that many genes preferentially expressed in the oocytes are misregulated by Sohlh1 and/or Sohlh2 deficiency.
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| Overall design |
Total RNA samples isolated from wildtype, Sohlh1 KO and Sohlh2 KO mouse newborn ovaries were arrayed on the Illumina BeadChip MouseWG-6 2.0 arrays. We have 4 replicates for wildtype and Sohlh1 KO and 3 replicates for Sohlh2 KO.
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| Contributor(s) |
Ahn HW |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 20, 2010 |
| Last update date |
Jan 16, 2019 |
| Contact name |
Aleksandar Rajkovic |
| E-mail(s) |
rajkovic@upmc.edu
|
| Phone |
412-641-7457
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| Fax |
412-641-8519
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| Organization name |
Magee-Womens Research Institute
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| Department |
Dept. of Obstetrics, Gynecology & Reproductive Sciences
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| Street address |
204 Craft Ave. Suite A230
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| City |
Pittsburgh |
| State/province |
PA |
| ZIP/Postal code |
15213 |
| Country |
USA |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (11)
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| This SubSeries is part of SuperSeries: |
| GSE24817 |
Regulation of early folliculogenesis by Sohlh1 and Sohlh2 in mouse ovary |
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| Relations |
| BioProject |
PRJNA133645 |
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