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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Jan 31, 2011 |
| Title |
Bile acids promote adenocarcinoma in a novel transgenic mouse model of Barrett’s esophagus |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Esophageal adenocarcinoma (EAC) has the fastest increase of any cancer in the US and Europe, and arises in the setting of Barrett’s esophagus (BE), defined by replacement of normal squamous epithelium with columnar intestinal-like epithelium. BE is thought to result from chronic esophageal inflammation but has been elusive to model in animals. Herein, we have generated the first transgenic mouse model of Barrett’s esophagus through overexpression of interleukin-1ß (IL-1β). IL-1β overexpression in the mouse esophageal mucosa induces chronic inflammation that progresses to intestinal metaplasia, with characteristic expression of TFF2, Bmp4 and Cdx2. With aging, IL-1b transgenic mice progress to esophageal adenocarcinoma (EAC) but the process is markedly accelerated by exposure to bile acids and/or nitrosamines, resembling the human counterpart. Moreover, progenitor cells present in the gastric cardia, but absent from the esophagus in humans and mice, are increased in BE, suggesting the cell of origin in the gastric cardia
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| Overall design |
Comparison of BE and EAC tissue from the mouse with normal squamous epithelium from the mouse.
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| Contributor(s) |
Quante M, Bhagat G, Abrams J, Marache F, Good P, Lee MD, Mahmood U, Figueiredo J, Lightdale C, Rustgi A, Friedman R, Wang TC |
| Citation(s) |
22264787 |
| Submission date |
Oct 26, 2010 |
| Last update date |
Apr 30, 2019 |
| Contact name |
Michael Quante |
| E-mail(s) |
michael.quante@tum.de
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| Organization name |
Technische Universität München
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| Department |
II Medizinische Klinik
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| Street address |
Ismaninger Str 22
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| City |
München |
| ZIP/Postal code |
81675 |
| Country |
Germany |
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| Platforms (1) |
| GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA131921 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE24931_RAW.tar |
15.8 Mb |
(http)(custom) |
TAR |
| GSE24931_SampleProbeFinalReport_nonorm.txt.gz |
12.9 Mb |
(ftp)(http) |
TXT |
| GSE24931_SampleProbeFinalReport_quantile.txt.gz |
12.8 Mb |
(ftp)(http) |
TXT |
| GSE24931_SampleTableFinalReport.txt.gz |
996 b |
(ftp)(http) |
TXT |
| GSE24931_non_normalized.txt.gz |
2.3 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
| Processed data are available on Series record |
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