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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Dec 20, 2010 |
| Title |
Gene expression profiling of spleen marginal zone B cells and spleen follicular B cells in IRF8 conditional KO mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Conditional IRF8 KO mice (mice with a conditional allele of Irf8 crossed with CD19-Cre mice) showed increased numbers of both Gene expression data spleen marginal zone (MZ) and Gene expression data spleen follicular (FO) B cells compared to control mice.
To evaluate gene expression patterns that distinguished FO or MZ B cells derived from conditional KO and control mice, we used Affymetrix GeneChip® Mouse gene 1.0 ST Array.
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| Overall design |
FACS-sorted MZ and FO B cells from individual mouse were used for RNA extraction and Affyarray hybridization. There were six independent biological replications in each group - six cases of MZ B cells and FO cells in IRF8 conditional KO mice and six cases of MZ B cells and FO cells in control WT mice.
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| Contributor(s) |
Feng J, Wang H, Shin D, Masiuk M, Qi C, Morse HC |
| Citation(s) |
21178004 |
| Submission date |
Oct 27, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Dong-Mi Shin |
| E-mail(s) |
shindm@snu.ac.kr
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| Organization name |
seoul national university
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| Street address |
1 gwanak-ro
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| City |
Seoul |
| ZIP/Postal code |
151742 |
| Country |
South Korea |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (24)
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| GSM613485 |
spleen marginal zone B in WT, biological rep1 |
| GSM613486 |
spleen marginal zone B in WT, biological rep2 |
| GSM613487 |
spleen marginal zone B in WT, biological rep3 |
| GSM613488 |
spleen marginal zone B in WT, biological rep4 |
| GSM613489 |
spleen marginal zone B in WT, biological rep5 |
| GSM613490 |
spleen marginal zone B in WT, biological rep6 |
| GSM613491 |
spleen marginal zone B in IRF8 conditional KO, biological rep1 |
| GSM613492 |
spleen marginal zone B in IRF8 conditional KO, biological rep2 |
| GSM613493 |
spleen marginal zone B in IRF8 conditional KO, biological rep3 |
| GSM613494 |
spleen marginal zone B in IRF8 conditional KO, biological rep4 |
| GSM613495 |
spleen marginal zone B in IRF8 conditional KO, biological rep5 |
| GSM613496 |
spleen marginal zone B in IRF8 conditional KO, biological rep6 |
| GSM613497 |
spleen follicular B in WT, biological rep1 |
| GSM613498 |
spleen follicular B in WT, biological rep2 |
| GSM613499 |
spleen follicular B in WT, biological rep3 |
| GSM613500 |
spleen follicular B in WT, biological rep4 |
| GSM613501 |
spleen follicular B in WT, biological rep5 |
| GSM613502 |
spleen follicular B in WT, biological rep6 |
| GSM613503 |
spleen follicular B in IRF8 conditional KO, biological rep1 |
| GSM613504 |
spleen follicular B in IRF8 conditional KO, biological rep2 |
| GSM613505 |
spleen follicular B in IRF8 conditional KO, biological rep3 |
| GSM613506 |
spleen follicular B in IRF8 conditional KO, biological rep4 |
| GSM613507 |
spleen follicular B in IRF8 conditional KO, biological rep5 |
| GSM613508 |
spleen follicular B in IRF8 conditional KO, biological rep6 |
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| Relations |
| BioProject |
PRJNA131901 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE24972_RAW.tar |
110.1 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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