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Series GSE25062 Query DataSets for GSE25062
Status Public on Jun 03, 2011
Title Genome-scale analysis of aberrant DNA methylation in colorectal cancer
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary To characterize DNA methylation-based subgroups in colorectal cancer, we performed genome-scale DNA methylation profiling of 125 colorectal tumor samples and 29 histologically normal-adjacent colonic tissue samples using the Illumina Infinium DNA methylation assay, which assesses the DNA methylation status of 27,578 CpG sites located at the promoter regions of 14,495 protein-coding genes. We identified four DNA methylation-based subgroups of CRC using model-based cluster analyses. Each subtype shows characteristic genetic and clinical features, indicating that they represent biologically distinct subgroups.
 
Overall design Bisulfite converted DNA from fresh frozen 125 colorectal tumors and 29 adjacent normal tissues were hybridized to the Illumina Infinium 27k Human Methylation Beadchip v1.2
 
Contributor(s) Hinoue T, Weisenbuerger DJ, Pan F, Laird PW
Citation(s) 21659424
Submission date Nov 01, 2010
Last update date Jan 02, 2015
Contact name Toshinori Hinoue
E-mail(s) thinoue@usc.edu
Phone 323-442-7458
Organization name USC Epigenome Center
Street address 1450 Biggy Street, NRT G511
City Los Angeles
State/province CA
ZIP/Postal code 90033-9601
Country USA
 
Platforms (1)
GPL8490 Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2)
Samples (154)
GSM615453 Colorectal Adenocarinoma 14801
GSM615454 Colorectal Adenocarinoma 14802
GSM615455 Colorectal Adenocarinoma 14803
Relations
BioProject PRJNA134727

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE25062_RAW.tar 67.9 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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