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Series GSE25071 Query DataSets for GSE25071
Status Public on Sep 07, 2011
Title Gene expression comparison of colorectal cancer samples from patients diagnosed at a young and elderly age
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Colorectal cancer (CRC) incidence increases with age and early onset of the disease is an indication of genetic predisposition, estimated to cause up to 30 % of all CRC cases. To identify genes associated with an increased risk for CRC, genome-wide gene expression levels of CRCs from patients diagnosed at an early age and CRCs from patients diagnosed at higher age were investigated. Patients with known hereditary predisposition syndromes were excluded from the study.
Overall design Twenty four patients were diagnosed at a young age (mean, 43 years; range, 28-53 years), referred to as the early onset group. They were excluded from the HNPCC and FAP syndromes by clinical criteria and no other cancer syndromes were recorded for these patients. The second group consisted of 17 patients with primary diagnosis at old age (mean, 79 years; range, 69-87 years), referred to as the late onset group. The samples from the late onset group were selected to reflect the composition of the early onset group with respect to gender, tumor localization and tumor stage according to The International Union Against Cancer (UICC)/American Joint Committee on Cancer (AJCC). Microsatellite instability (MSI) status was previously analyzed in all samples to eliminate the potential risk of including patients with inherited DNA repair deficiencies.
Contributor(s) Ågesen TH, Berg M, Thiis-Evensen E, Cekaite L, Lind GE, Nesland JM, Bakka A, Mala T, Hauss HJ, Fetveit T, Nesbakken A, Lothe RA, Skotheim RI
Citation(s) 21716316, 21909432
Submission date Nov 01, 2010
Last update date Sep 24, 2019
Contact name Trude Holmeide Ågesen
Organization name Oslo University Hospital
Department Department of Cancer Prevention
Street address Ullernch. 70
City Oslo
ZIP/Postal code 0310
Country Norway
Platforms (1)
GPL2986 ABI Human Genome Survey Microarray Version 2
Samples (50)
GSM615917 HB006YP_9/19/07_10:42_AM
GSM615918 HB006Z1_10/19/07_10:02_AM
GSM615919 HB006YX_1/23/08_11:42_AM
BioProject PRJNA134735

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE25071_RAW.tar 84.1 Mb (http)(custom) TAR (of TXT)
Raw data provided as supplementary file
Processed data included within Sample table

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