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Series GSE25182 Query DataSets for GSE25182
Status Public on Nov 10, 2010
Title tTA/TDP Mice Expression Array
Organism Mus musculus
Experiment type Expression profiling by array
Summary Transgenic (Tg) mice expressing nuclear or cytoplasmic human TDP-43 were generated.
Tg mice had motor spasticity and forebrain neurodegeneration.
Human TDP-43 reduced mouse TDP-43 in nuclei of affected neurons.
Tg mice showed alterations in transcripts related to chromatin assembly.
 
Overall design Cerebral cortex from 21 transgenic mice and controls were assayed after two weeks off doxycyline diet as described in Igaz et al.
 
Contributor(s) Lee V
Citation(s) 21206091
Submission date Nov 08, 2010
Last update date May 04, 2018
Contact name Virginia M.-Y. Lee
Organization name University of Pennsylvania
Street address 3rd Floor Maloney Building; 3600 Spruce St
City Philadelphia
ZIP/Postal code 19104
Country USA
 
Platforms (1)
GPL8321 [Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array
Samples (21)
GSM618442 tTA/TDP-DeltaNLS_3275_14201_1_MOE430A_v2.0
GSM618443 tTA/TDP-DeltaNLS_3275_14202_2_MOE430A_v2.0
GSM618444 tTA/TDP-DeltaNLS_3275_14203_3_MOE430A_v2.0
Relations
BioProject PRJNA134527

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE25182_RAW.tar 43.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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