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Series GSE25278 Query DataSets for GSE25278
Status Public on Nov 13, 2010
Title Gp130-dependent release of acute phase proteins is linked to the activation of innate immune signaling pathways
Organism Mus musculus
Experiment type Expression profiling by array
Summary Gp130 dependent gene expression was analyzed in a previously established hepatocyte-specific gp130-knockout mouse model. Whole transcriptome analysis for isolated hepatocytes was performed to measure tissue specific responses after proinflammatory stimulus with IL-6 across different time points. We observed differences in the hepatocyte-specific transcriptional gp130 dependent response for genes associated with different aspects of the innate immune system. Our findings suggest a complex network of tightly-linked genes involved in the early activation of different parts of the innate immune response including acute phase proteins, complement and coagulation cascade.
 
Overall design Total RNA obtained from a total number of 61 samples of isolated hepatocytes of hepatocyte-specific gp130-knockout and gp130flox mice, which were subjected to Il-6 treatment for 0, 1, 3, 6 or 12 hours, respectively.
 
Contributor(s) Luchtefeld M, Preuss C, Rühle F, Bogalle EP, Sietmann A, Figura S, Müller W, Schieffer B, Stoll M
Citation(s) 21573245
Submission date Nov 10, 2010
Last update date Jan 16, 2019
Contact name Frank Ruehle
E-mail(s) frank.ruehle@lifa-muenster.de
Organization name Leibniz - Institut für Arterioskleroseforschung
Street address Domagkstr. 3
City Münster
ZIP/Postal code 48149
Country Germany
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (61)
GSM621970 WT mouse unstimulated rep1
GSM621971 WT mouse unstimulated rep2
GSM621972 WT mouse unstimulated rep3
Relations
BioProject PRJNA134817

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE25278_RAW.tar 15.8 Mb (http)(custom) TAR
GSE25278_non-normalized.txt.gz 17.0 Mb (ftp)(http) TXT
Processed data included within Sample table

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