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| Status |
Public on Jul 18, 2005 |
| Title |
Assessment of gene expression changes during palatal adherence and epithelial-mesenchymal transformation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Genomic analysis was performed to distinguish expression changes in murine medial edge epithelial cells during both palatal adherence and epithelial-mesenchymal transformation (EMT). Assessment of changes between sample 0 hours and sample 12 hours represent palatal adherence. Changes between sample 12 hours and sample 24 hours represent EMT.
During adherence, we found that genes necessary for TGF-beta/LEF-1 signal transduction upregulate, as well as those necessary for cell adhesion. During EMT, we observed the loss of epithelial markers and upregulation of many genes necessary to promote the transition to mesenchyme and cell migration.
Keywords = EMT
Keywords = palate
Keywords = LEF-1
Keywords = TGF-beta
Keywords = craniofacial development
Keywords: time-course
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| Contributor(s) |
LaGamba D, Nawshad A, Hay ED |
| Citation(s) |
16010672 |
| Submission date |
Apr 18, 2005 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Damian LaGamba |
| E-mail(s) |
damian_lagamba@hms.harvard.edu
|
| Phone |
617-869-2130
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| Organization name |
Harvard Medical School
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| Department |
Cell Biology
|
| Street address |
220 Longwood Ave.
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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| Samples (3) |
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| Relations |
| BioProject |
PRJNA92693 |
