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| Status |
Public on Dec 31, 2011 |
| Title |
Genome-wide Transcriptional Analysis of Genes Associated with Desiccation Stress in Anopheles gambiae |
| Platform organisms |
Plasmodium falciparum; Anopheles gambiae |
| Sample organism |
Anopheles gambiae |
| Experiment type |
Expression profiling by array
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| Summary |
Anopheles gambiae mosquitoes play an important role in malaria transmission. In sub-Saharan Africa, the dry season can last several months. The mechanisms for mosquito population to survive through the dry season are poorly understood. One possible mechanism is that adults increase their desiccation tolerance over the dry season. Genetic analyses have shown that inversions 2La, 2Rb, 2Rc, 2Rd and 2Ru are associated with aridity resistance, however little is known about the transcriptional response of genes in response to desiccation.
The results of the present study demonstrate that desiccation affects expression of genes associated with several mosquito physiological mechanisms, including those that protect against water loss, but all structural related genes decreased their expression. The identified differentially expressed genes in response to desiccation stress can lay a foundation for better understanding of molecular mechanisms underling dry-season survival of An. gambiae mosquitoes, so it may provide a different option for malaria vector control.
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| Overall design |
Transcriptional profiles of Anopheles gambiae female mosquitoes were exposed to 70% (standard) or 30% (desiccated) RH without any access to sugar and water at 0hr, 18hr or 36hr.
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| Contributor(s) |
Wang M |
| Citation(s) |
21991392 |
| Submission date |
Nov 17, 2010 |
| Last update date |
Jan 24, 2013 |
| Contact name |
Mei-Hui Wang |
| E-mail(s) |
meihuiw@uci.edu
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| Phone |
949-824-0249
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| Fax |
949-824-0249
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| Organization name |
UC irvine
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| Street address |
3501B Hewitt Hall UCI
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| City |
Irvine |
| State/province |
CA |
| ZIP/Postal code |
92697 |
| Country |
USA |
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| Platforms (1) |
| GPL1321 |
[Plasmodium_Anopheles] Affymetrix Plasmodium/Anopheles Genome Array |
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| Samples (19)
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| GSM624288 |
No desiccation stress exposure, biological rep1 |
| GSM624289 |
No desiccation stress exposure, biological rep2 |
| GSM624290 |
No desiccation stress exposure, biological rep3 |
| GSM624291 |
No desiccation stress exposure, biological rep4 |
| GSM624292 |
Exposed to 30% RH for 18hr , biological rep1 |
| GSM624293 |
Exposed to 30% RH for 18hr , biological rep2 |
| GSM624294 |
Exposed to 30% RH for 18hr , biological rep3 |
| GSM624295 |
Exposed to 30% RH for 18hr , biological rep4 |
| GSM624296 |
Exposed to 70% RH for 18hr , biological rep1 |
| GSM624297 |
Exposed to 70% RH for 18hr , biological rep2 |
| GSM624298 |
Exposed to 70% RH for 18hr , biological rep3 |
| GSM624299 |
Exposed to 70% RH for 18hr , biological rep4 |
| GSM624300 |
Exposed to 30% RH for 36hr , biological rep1 |
| GSM624301 |
Exposed to 30% RH for 36hr , biological rep2 |
| GSM624302 |
Exposed to 30% RH for 36hr , biological rep3 |
| GSM624303 |
Exposed to 70% RH for 36hr , biological rep1 |
| GSM624304 |
Exposed to 70% RH for 36hr , biological rep2 |
| GSM624305 |
Exposed to 70% RH for 36hr , biological rep3 |
| GSM624306 |
Exposed to 70% RH for 36hr , biological rep4 |
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| Relations |
| BioProject |
PRJNA133789 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE25433_RAW.tar |
41.2 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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