|
| Status |
Public on Dec 03, 2010 |
| Title |
Effects of redox modulation by inhibition of Thioredoxin reductase on radiosensitivity and gene expression |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
The involvement the thioredoxin system in radiation resistance was investigated in human lung cancer cells by a combination of ionizing radiation and specific thioredoxin reductase-inhibition by a phosphine gold compound.
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| |
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| Overall design |
Gene expression profiles (Human Gene 1.0 ST) of lung cancer cells subjected to ionizing radiation and/or inhibition of thioredoxin reductase were studied. Data analyses were performed using the Affymetrix GeneChip Operating Software (GCOS) Version 1.4.
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| |
|
| Contributor(s) |
Selenius M, Brodin D |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 02, 2010 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Markus Selenius |
| Organization name |
Karolinska Institutet
|
| Department |
Laboratory Medicine
|
| Lab |
Division of Pathology
|
| Street address |
Karolinska University Hospital, Huddinge F46
|
| City |
Stockholm |
| ZIP/Postal code |
14186 |
| Country |
Sweden |
| |
|
| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (14)
|
| GSM634266 |
LungcancerCellLine_unirradiated_uninhibited_rep1 |
| GSM634267 |
LungcancerCellLine_unirradiated_uninhibited_rep2 |
| GSM634268 |
LungcancerCellLine_unirradiated_uninhibited_rep3 |
| GSM634269 |
LungcancerCellLine_irradiated_uninhibited_rep1 |
| GSM634270 |
LungcancerCellLine_irradiated_uninhibited_rep2 |
| GSM634271 |
LungcancerCellLine_irradiated_uninhibited_rep3 |
| GSM634272 |
LungcancerCellLine_unirradiated_TrxRinhibited_rep1 |
| GSM634273 |
LungcancerCellLine_unirradiated_TrxRinhibited_rep2 |
| GSM634274 |
LungcancerCellLine_unirradiated_TrxRinhibited_rep3 |
| GSM634275 |
LungcancerCellLine_irradiated_TrxRinhibited_rep1 |
| GSM634276 |
LungcancerCellLine_irradiated_TrxRinhibited_rep2 |
| GSM634277 |
LungcancerCellLine_irradiated_TrxRinhibited_rep3 |
| GSM634278 |
LungcancerCellLine_unirradiated_siRNA_TrxR1_rep1 |
| GSM634279 |
LungcancerCellLine_unirradiated_siRNA_neg.control_rep2 |
|
| Relations |
| BioProject |
PRJNA135619 |
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