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| Status |
Public on Dec 07, 2010 |
| Title |
Early target genes of aflatoxin B1 in human hepatic cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Comparison of gene expression profiles induced by the mycotoxin, aflatoxin B1 (AFB1), in primary human hepatocytes and HepaRG cells.
Initial mechanisms involved in the complex multistep process leading to malignant transformation by chemicals remain largely unknown. We have analysed changes in gene expression profiles in primary human hepatocytes and differentiated human hepatoma HepaRG cells after a 24 h treatment with 0.05 or 0.25µM aflatoxin B1 (AFB1), a potent genotoxic hepatocarcinogen.
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| Overall design |
Three independent biological replicates of HepaRG cell cultures and two pools of three primary human hepatocyte cultures each, were investigated. Cells were treated with 0.05 or 0.25µM AFB1 for 24 h.
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| Contributor(s) |
Jossé R, Rogue A, Lambert C |
| Citation missing |
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| Submission date |
Dec 03, 2010 |
| Last update date |
Feb 22, 2018 |
| Contact name |
rozenn jossé |
| E-mail(s) |
rozenn.josse@univ-rennes1.fr
|
| Organization name |
INSERM U991
|
| Street address |
2 av Prof Léon Bernard
|
| City |
Rennes |
| ZIP/Postal code |
35043 |
| Country |
France |
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| Platforms (1) |
| GPL4133 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Feature Number version) |
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| Samples (22)
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| Relations |
| BioProject |
PRJNA135761 |
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