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Series GSE25871 Query DataSets for GSE25871
Status Public on Jan 01, 2012
Title Human Beta-Defensin 3 attenuates the pro-inflammatory effects of KDO2-Lipid A (KLA) at 6 hour
Organism Mus musculus
Experiment type Expression profiling by array
Summary We examine the global effect of hBD3 on transcription in TLR4-stimulated macrophages and for the first time show that hBD3 inhibits the transcription of critical pro-inflammatory genes.
Among the repressed genes we detect significant enrichment of groups involved in the positive regulation of NFkappaB including components of Toll-like receptor signaling pathways.
 
Overall design Total RNA obtained from bone marrow derived macrophages (BMDM) that have been subjected to 6 hour treatment with KLA, KLA&hBD3, hBD3 or untreated. There are 3 biological replicates per group.
 
Contributor(s) Semple F, Dorin JR, Webb S, Grimes GR, Semple CA
Citation(s) 21809339
Submission date Dec 06, 2010
Last update date Aug 14, 2019
Contact name Graeme Richard Grimes
E-mail(s) graeme.grimes@ed.ac.uk
Organization name University of Edinburgh, The Institute of Genetics and Cancer
Department Human Genetics Unit
Lab Bioinformatics Analysis Core
Street address Western General Hospital, Crewe Road
City Edinburgh
ZIP/Postal code EH4 2XU
Country United Kingdom
 
Platforms (1)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
Samples (12)
GSM635224 KLA 6hrs BMDM rep1
GSM635225 KLA & hBD3 6hrs BMDM rep1
GSM635226 KLA 6hrs HBD3 rep2
This SubSeries is part of SuperSeries:
GSE25873 Effect of hBD3 on transcription in TLR4-stimulated macrophages
Relations
BioProject PRJNA142473

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE25871_RAW.tar 15.8 Mb (http)(custom) TAR
GSE25871_non-normalized_data.txt.gz 3.6 Mb (ftp)(http) TXT
Processed data included within Sample table

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