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Status |
Public on Jan 01, 2012 |
Title |
Human Beta-Defensin 3 attenuates the pro-inflammatory effects of KDO2-Lipid A (KLA) at 6 hour |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
We examine the global effect of hBD3 on transcription in TLR4-stimulated macrophages and for the first time show that hBD3 inhibits the transcription of critical pro-inflammatory genes. Among the repressed genes we detect significant enrichment of groups involved in the positive regulation of NFkappaB including components of Toll-like receptor signaling pathways.
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Overall design |
Total RNA obtained from bone marrow derived macrophages (BMDM) that have been subjected to 6 hour treatment with KLA, KLA&hBD3, hBD3 or untreated. There are 3 biological replicates per group.
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Contributor(s) |
Semple F, Dorin JR, Webb S, Grimes GR, Semple CA |
Citation(s) |
21809339 |
Submission date |
Dec 06, 2010 |
Last update date |
Aug 14, 2019 |
Contact name |
Graeme Richard Grimes |
E-mail(s) |
graeme.grimes@ed.ac.uk
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Organization name |
University of Edinburgh, The Institute of Genetics and Cancer
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Department |
Human Genetics Unit
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Lab |
Bioinformatics Analysis Core
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Street address |
Western General Hospital, Crewe Road
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City |
Edinburgh |
ZIP/Postal code |
EH4 2XU |
Country |
United Kingdom |
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Platforms (1) |
GPL6887 |
Illumina MouseWG-6 v2.0 expression beadchip |
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Samples (12)
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This SubSeries is part of SuperSeries: |
GSE25873 |
Effect of hBD3 on transcription in TLR4-stimulated macrophages |
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Relations |
BioProject |
PRJNA142473 |