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| Status |
Public on Dec 10, 2010 |
| Title |
Transcriptional Profiling of Human Placentas from Pregnancies Complicated by Preeclampsia Reveals Disregulation of Sialic Acid Acetylesterase and Immune Signaling Pathways |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The placenta plays an important role as a regulator of fetal nutrition and growth throughout development and placental factors contribute to gestational abnormalities such as preeclampsia. This study describes the genome-wide gene expression profiles of a large (n=60) set of human placentas in order to uncover gene expression patterns associated with preeclampsia. In addition to confirming changes in expression of soluble factors associated with preeclampsia such as sFLT1 (soluble fms-like tyrosine kinase-1), sENG (soluble endoglin), and INHA (inhibin alpha), we also find changes in immune-associated signaling pathways, offering a potential upstream explanation for the shallow trophoblast invasion and inadequate uterine remodeling typically observed in pathogenesis of preeclampsia. Notably, we also find evidence of preeclampsia-associated placental upregulation of sialic acid acetylesterase (SIAE), a gene functionally associated with autoimmune diseases.
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| Overall design |
23 preeclamptic, and 37 control placentas included in this study were collected during the years of 2004-2008 and hybridized in two batches to microarrays. Samples were randomized across arrays to control for array and batch variability.
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| Contributor(s) |
Tsai S, Hardison NE, James AH, Motsinger-Reif AA, Bischoff SR, Thames BH, Piedrahita JA |
| Citation(s) |
21183218 |
| Submission date |
Dec 07, 2010 |
| Last update date |
Nov 13, 2015 |
| Contact name |
Shengdar Tsai |
| Organization name |
North Carolina State University
|
| Street address |
4700 Hillsborough St.
|
| City |
Raleigh |
| State/province |
NC |
| ZIP/Postal code |
27604 |
| Country |
USA |
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| Platforms (1) |
| GPL6102 |
Illumina human-6 v2.0 expression beadchip |
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| Samples (60)
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| Relations |
| BioProject |
PRJNA135777 |
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