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| Status |
Public on May 06, 2005 |
| Title |
Gene expressing profiling of PC12 cells expressing the FGFR3 mutation responsible for thanatophoric dysplasia type II |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
To investigate signaling pathways activated by FGFR3 mutations through an analysis of altered expression of downstream transcriptional targets, we performed gene expression profiling of stably transfected inducible PC12 cells expressing a chimeric receptor (PFR3) consisting of the extracellular domain of human platelet derived growth factor receptor (PDGFR) and the transmembrane and intracellular domains of human FGFR3 under the control of the zinc inducible metalliothionein promoter. Cells expressing the wildtype receptor (i.e. zinc induced) were compared to cells expressing the mutant receptor PFR3K650E, which contains the thanatophoric dysplasia type II mutation, K650E. See PubMed ID for further description of samples.
Keywords = thanatophoric dysplasia
Keywords = FGFR3
Keywords = PC12
Keywords = ERK1/2
Keywords: repeat sample
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| Contributor(s) |
Nowroozi N, Raffioni S, Wang T, Apostol BL, Bradshaw RA, Thompson LM |
| Citation(s) |
15843401 |
| Submission date |
May 03, 2005 |
| Last update date |
Feb 21, 2017 |
| Contact name |
Barbara Apostol |
| E-mail(s) |
blaposto@uci.edu
|
| Phone |
(949) 824-9784
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| Organization name |
University of California Irvine
|
| Department |
Psychiratry and Human Behavior
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| Street address |
|
| City |
Irvine |
| State/province |
CA |
| ZIP/Postal code |
92697 |
| Country |
USA |
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| Platforms (1) |
| GPL85 |
[RG_U34A] Affymetrix Rat Genome U34 Array |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA92147 |
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