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| Status |
Public on Jun 09, 2011 |
| Title |
Notch signaling in CD66+ cells drives the progression of human cervical cancers |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Microarry based whole genome expression analysis was done for the more tumorigenic CaSki spheroids cultures and the less tumorigenic CaSki adherent cultures to identify signaling mechanisms that vary between the two populations. Subsequent to this, an independent array was done to characterize the differences in gene expression between the Lin-CD66+ and the Lin- CD66- cells isolated from primary human cervical carcinomas. The second array was custom-designed and had genes implicated in stemness, epithelial differentiation, signaling pathways implicated in stemness (Notch and Wnt) and cell cylce-regulation.
This SuperSeries is composed of the SubSeries listed below.
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| |
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| Overall design |
Refer to individual Series.
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| |
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| Contributor(s) |
Krishna S, Bajaj J, Vivien E |
| Citation(s) |
21646470 |
| Submission date |
Jan 04, 2011 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Sudhir Krishna |
| E-mail(s) |
skrishna@ncbs.res.in
|
| Organization name |
National Centre for Biological Sciences, TIFR
|
| Street address |
UAS-GKVK Campus, Bellary Road
|
| City |
Bangalore |
| State/province |
Karnataka |
| ZIP/Postal code |
560065 |
| Country |
India |
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| Platforms (2) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
| GPL11337 |
Agilent-027242 Genotypic Technology Pvt. Ltd. designed human gene expression microarray (Probe Name version) |
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| Samples (9)
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| This SuperSeries is composed of the following SubSeries: |
| GSE26417 |
Microarray analysis of CaSki cell line grown as spheroids and adherent conditions |
| GSE26418 |
Microarray analysis of Lin- CD66+ and Lin- CD66- cells isolated from primary human cervical cancer |
|
| Relations |
| BioProject |
PRJNA136795 |
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