|
| Status |
Public on Jan 20, 2011 |
| Title |
Expression data from Tregs adoptively transferred in MHC II competent or deficient recipients |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Disruption of TCR /MHC class II interactions leads rapidly to alterations of the common CD4 Treg transcriptional signature
Self-deprived, non-functional Tregs were compare to fully functional Tregs by microarrays.
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| Overall design |
Total T cells from the periphery of WT mice were adoptively transferred into CD3ε-/- recipient mice lacking or not MHC class II molecule expression (MHC II- or MHC II+ recipient mice, respectively). Five days later, peripheral Tregs transferred in MHC II - competent (CD4CD25B6) or - deficient (CD4CD25IIko) recipient were purified for RNA extraction and hybridization on Affymetrix microarrays.
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| Contributor(s) |
Lucas B |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 19, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Florent Dumont |
| E-mail(s) |
florent.dumont@u-psud.fr
|
| Organization name |
Université Paris-Saclay
|
| Street address |
17 avenue des sciences
|
| City |
91400 Orsay |
| State/province |
Ile de France |
| ZIP/Postal code |
91400 |
| Country |
France |
| |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (6)
|
| GSM657838 |
Tregs purified from MHC II competent recipient, Biological Rep1 |
| GSM657839 |
Tregs purified from MHC II competent recipient, Biological Rep2 |
| GSM657840 |
Tregs purified from MHC II competent recipient, Biological Rep3 |
| GSM657841 |
Tregs purified from MHC II deficient recipient, Biological Rep1 |
| GSM657842 |
Tregs purified from MHC II deficient recipient, Biological Rep2 |
| GSM657843 |
Tregs purified from MHC II deficient recipient, Biological Rep3 |
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| This SubSeries is part of SuperSeries: |
| GSE27153 |
Expression data from self-deprived regulatory CD4 T cells |
|
| Relations |
| BioProject |
PRJNA142147 |
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