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GEO help: Mouse over screen elements for information. |
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Status |
Public on Feb 21, 2013 |
Title |
Expression data from human lung cancer cell lines with NEDD9 overexpression or NEDD9 knockdown |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
NEDD9 is important for lung cancer metastasis. However, the detailed mechanism remains elusive. Using the microarray data generated with human lung cancer cell lines with either NEDD9 overexpression or NEDD9 knockdown, we plan to idnetify important signal pathways regulated by NEDD9. This may explain how NEDD9 excutes its function in lung cancer. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.
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Overall design |
Human lung cancer cell line A549, which has LKB1 loss-of-function mutation and increased expression of NEDD9, was used for two individual NEDD9 knockdown. Human lung cancer cell line CRL-5907, which has wild-type LKB1 and low NEDD9 expression level, was used for NEDD9 overexpression. The microarray was done in A549 cells, A549 cells with two different NEDD9 knockdown; CRL-5907 cells and CRL-5907 cells with NEDD9 overexpression.
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Contributor(s) |
Feng Y, Fang Z, Ji H |
Citation(s) |
24174333 |
Submission date |
Jan 25, 2011 |
Last update date |
Feb 18, 2019 |
Contact name |
Hongbin Ji |
E-mail(s) |
hbji@sibs.ac.cn
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Organization name |
Shanghai Institutes for Biological Sciences
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Street address |
320 Yue Yang Road
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City |
Shanghai |
ZIP/Postal code |
200031 |
Country |
China |
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Platforms (1) |
GPL5175 |
[HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version] |
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Samples (5)
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Relations |
BioProject |
PRJNA135965 |
Supplementary file |
Size |
Download |
File type/resource |
GSE26846_RAW.tar |
104.3 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
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