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Series GSE26846 Query DataSets for GSE26846
Status Public on Feb 21, 2013
Title Expression data from human lung cancer cell lines with NEDD9 overexpression or NEDD9 knockdown
Organism Homo sapiens
Experiment type Expression profiling by array
Summary NEDD9 is important for lung cancer metastasis. However, the detailed mechanism remains elusive. Using the microarray data generated with human lung cancer cell lines with either NEDD9 overexpression or NEDD9 knockdown, we plan to idnetify important signal pathways regulated by NEDD9. This may explain how NEDD9 excutes its function in lung cancer.
We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.
 
Overall design Human lung cancer cell line A549, which has LKB1 loss-of-function mutation and increased expression of NEDD9, was used for two individual NEDD9 knockdown. Human lung cancer cell line CRL-5907, which has wild-type LKB1 and low NEDD9 expression level, was used for NEDD9 overexpression. The microarray was done in A549 cells, A549 cells with two different NEDD9 knockdown; CRL-5907 cells and CRL-5907 cells with NEDD9 overexpression.
 
Contributor(s) Feng Y, Fang Z, Ji H
Citation(s) 24174333
Submission date Jan 25, 2011
Last update date Feb 18, 2019
Contact name Hongbin Ji
E-mail(s) hbji@sibs.ac.cn
Organization name Shanghai Institutes for Biological Sciences
Street address 320 Yue Yang Road
City Shanghai
ZIP/Postal code 200031
Country China
 
Platforms (1)
GPL5175 [HuEx-1_0-st] Affymetrix Human Exon 1.0 ST Array [transcript (gene) version]
Samples (5)
GSM660686 A549, control
GSM660687 A549, shNEDD9 #1 knockdown
GSM660688 A549, shNEDD9 #2 knockdown
Relations
BioProject PRJNA135965

Download family Format
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Supplementary file Size Download File type/resource
GSE26846_RAW.tar 104.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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