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Series GSE26948 Query DataSets for GSE26948
Status Public on Jan 29, 2011
Title Programming of marginal zone B cell fate by basic krüppel-like factor (BKLF/KLF3)
Organism Mus musculus
Experiment type Expression profiling by array
Summary Gene expression analysis of splenic follicular B cells and marginal zone B cells from B6 and CD19:KLF3 transgenic mice
Comparing KLF3-transgenic and non-transgenic follicular B cells by RNA-microarray revealed that KLF3 regulates a subset of genes that was similarly up-/downregulated upon normal MZ B cell differentiation. Indeed, KLF3 expression overcame the lack of MZ B cells caused by different genetic alterations, such as CD19-deficiency or blockade of B-cell activating factor (BAFF)-receptor signaling, indicating that KLF3 may complement alternative NF-κB signaling. Thus, KLF3 is a driving force towards MZ B cell maturation.
 
Overall design RNA of splenic follicular B cells and marginal zone B cells were obtained from 4 different mice per group (B6 and CD19:KLF3 mice). 16 samples = 8 individual mice x 2 B cell subsets.
 
Contributor(s) Agenès F, Goulet J, Loubert J, Kirberg J
Citation(s) 21297003
Submission date Jan 28, 2011
Last update date Jun 14, 2018
Contact name Jean-Philippe Goulet
E-mail(s) jp.goulet@umontreal.ca
Organization name Université de Montréal
Street address C.P. 6128, succursale Centre-ville
City Montréal
State/province Québec
ZIP/Postal code H3X 3J7
Country Canada
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (16)
GSM663460 Spleen MZB cells from B6 mouse #92758
GSM663461 Spleen Follicular B cells from B6 mouse #92758
GSM663462 Spleen MZB cells from CD19:KLF3 mouse #92759
Relations
BioProject PRJNA136951

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SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE26948_RAW.tar 3.1 Mb (http)(custom) TAR
GSE26948_non-normalized.txt.gz 1.7 Mb (ftp)(http) TXT
Raw data are available on Series record
Processed data included within Sample table

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