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Series GSE26989 Query DataSets for GSE26989
Status Public on Jan 01, 2012
Title DNA methylation analysis of ovarian cancers and normal peripheral blood lymphocyte DNA by Illumina Infinium platform
Organism Homo sapiens
Experiment type Methylation profiling by array
Summary We performed a genome-scale DNA methylation analysis of 41 ovarian tumors and 10 normal lymphocytic samples. We used the Illumina Infinium HumanMethylation27 Beadchip platform that interrogates the DNA methylation profiles of approximately 27,000 CpGs to identify sensitive markers for ovarian cancer detection. The 41 tumor samples included one mixed (clear cell and endometrioid) tumor, three clear cell carcinomas, four mucinous, four endometrioid, and 32 serous epithelial ovarian carcinomas. The lymphocytic DNA samples were obtained from 10 healthy older women.
 
Overall design DNA obtained from 41 ovarian cancer tissue samples and 10 peripheral blood leukocyte (PBL) samples was bisulfite converted and then hybridized to the Illumina Infinium 27k Human Methylation Beadchip v.1.2
biological replicate: sample WBC6, WBC11
biological replicate: sample WBC8, WBC12
 
Contributor(s) Campan M, Laird PW
Citation(s) 22163280
Submission date Jan 31, 2011
Last update date Jan 02, 2015
Contact name Mihaela Campan
E-mail(s) velicesc@usc.edu
Organization name University of Southern California
Street address 1441 Eastlake Ave
City Los Angeles
ZIP/Postal code 90033
Country USA
 
Platforms (1)
GPL8490 Illumina HumanMethylation27 BeadChip (HumanMethylation27_270596_v.1.2)
Samples (53)
GSM664832 genomic DNA from ovarian cancer tissue [12762]
GSM664833 genomic DNA from ovarian cancer tissue [12764]
GSM664834 genomic DNA from ovarian cancer tissue [12766]
Relations
BioProject PRJNA135939

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE26989_RAW.tar 5.8 Mb (http)(custom) TAR
GSE26989_non-normalized.txt.gz 8.7 Mb (ftp)(http) TXT
Processed data included within Sample table
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