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Series GSE27236 Query DataSets for GSE27236
Status Public on Dec 01, 2012
Title Gene expression analysis of cardiac left-ventricle tissue from hybrid mice harboring the Scn5a-1798insD/+ mutation
Organism Mus musculus
Experiment type Expression profiling by array
Summary Prolonged electrocardiographic indices reflecting myocardial impulse conduction and repolarization are risk factors for sudden cardiac death and drug-induced arrhythmia. The PR-interval, QRS-duration and QT-interval are heritable traits influenced by multiple genetic and environmental factors. The genetic underpinnings of these traits are still largely unknown. In this study, we leveraged the variability in cardiac gene expression and the variation in PR-, QRS- and QT-intervals among F2 mice harboring the cardiac sodium ion-channel mutation Scn5a-1798insD/+ derived from the 129P2-Scn5a1798insD/+ and FVB/NJ-Scn5a1798insD/+ cross, to isolate novel genes and biological pathways impacting on cardiac conduction and repolarization.
 
Overall design Cardiac left-ventricle total RNA from 120 F2-(129P2xFVBN/J)-Scn5a-1798insD/+ mice at 12 to 14 weeks old.
 
Contributor(s) Scicluna BP, Bezzina CR
Citation(s) 23236294, 25217174
Submission date Feb 11, 2011
Last update date Jun 14, 2018
Contact name Brendon Paul Scicluna
E-mail(s) b.scicluna@amsterdamumc.nl
Organization name Academic Medical Center
Street address Meibergdreef 9
City Amsterdam
ZIP/Postal code 1105AZ
Country Netherlands
 
Platforms (1)
GPL6885 Illumina MouseRef-8 v2.0 expression beadchip
Samples (120)
GSM673353 heart_Scn5a-1798insD/+ mutant [4700266019_A]
GSM673354 heart_Scn5a-1798insD/+ mutant [4700266019_B]
GSM673355 heart_Scn5a-1798insD/+ mutant [4700266019_C]
Relations
BioProject PRJNA137487

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE27236_RAW.tar 3.1 Mb (http)(custom) TAR
GSE27236_non-normalized.txt.gz 20.8 Mb (ftp)(http) TXT
Processed data included within Sample table
Raw data are available on Series record

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