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Series GSE27287 Query DataSets for GSE27287
Status Public on Aug 15, 2011
Title Delineation of Two Clinically and Molecularly Distinct Subgroups of Posterior Fossa Ependymoma.
Organism Homo sapiens
Experiment type Expression profiling by array
Genome variation profiling by genome tiling array
Summary Despite histological similarity of ependymomas from throughout the neuraxis, the disease likely comprises multiple independent entities, each with a distinct molecular pathogenesis. Transcriptional profiling of two large independent cohorts of ependymomas reveals the existence of two demographically, transcriptionally, genetically and clinically distinct groups of posterior fossa (PF) ependymoma. Group A patients are younger, have laterally located tumors with a balanced genome, and are much more likely to exhibit recurrence, metastasis, and death as compared to Group B patients. Identification and optimization of immunohistochemical markers for PF ependymoma subgroups allowed validation of our findings on a third group of independent ependymomas using a human ependymoma tissue microarray, and provides a tool for prospective prognostication and stratification of PF ependymoma patients.

This SuperSeries is composed of the SubSeries listed below.
 
Overall design Refer to individual Series
 
Citation(s) 21840481
Submission date Feb 14, 2011
Last update date Jan 23, 2019
Contact name Hendrik Witt
E-mail(s) h.witt@dkfz.de
Phone +496221424594
Fax +496221424639
Organization name German Cancer Research Center
Department Molecular Genetics
Lab Prof. Peter Lichter
Street address INF 580
City Heidelberg
State/province BW
ZIP/Postal code 69120
Country Germany
 
Platforms (2)
GPL6480 Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version)
GPL13171 German Cancer Research Center human 33K BAC array
Samples (151)
GSM674627 fresh-frozen tissue_1ep1
GSM674628 fresh-frozen tissue_1ep11
GSM674629 fresh-frozen tissue_1ep12
This SuperSeries is composed of the following SubSeries:
GSE27283 Human ependymoma samples [expression]
GSE27286 Human ependymoma samples, Subgrouping [aCGH - German Cancer Research Center human 33K BAC array]
Relations
BioProject PRJNA137331

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE27287_RAW.tar 1.1 Gb (http)(custom) TAR (of GPR, TXT)

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