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Series GSE27480 Query DataSets for GSE27480
Status Public on Sep 30, 2011
Title Gene-expression analysis of Oncostatin-M (OSM) signalling in cervical squamous cell carcinomas over-expressing the Oncostatin-M receptor (OSMR)
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The type II Oncostatin M receptor (OSMR) serves as the main binding site for the pleiotropic cytokine OSM. We have previously demonstrated a positive correlation between copy number driven OSMR over-expression and adverse clinical outcome in cervical tumours and have also established enhanced angiogenic, migratory and invasive potential as major consequences of OSMR over-expression using cell-line models of cervical cancer. By analysis of gene expression patterns in cell lines and tumours, this study now systematically defines cohorts of genes that are implicated for the phenotypes observed. Importantly, we have identified 15 OSM induced genes that are involved in at least one of these key functions and are up-regulated in both OSMR over-expressing cell-lines and tumours. These genes can serve as markers of OSM signalling in OSMR over-expressing SCCs and represent suitable targets for functional characterisation.
 
Overall design Gene expression of 4 cervical SCC cell lines analysed (2 with and 2 without OSMR overexpression) at 6 different time-points, with 3 replicates at each time-point.
 
Contributor(s) Chattopadhyay A, Bauer J, Roberts I, Zhang X, Karagavriilidou K, Winder D, Coleman N
Citation(s) 21952923
Submission date Feb 24, 2011
Last update date Feb 15, 2013
Contact name Julien Bauer
E-mail(s) jb393@cam.ac.uk
Organization name Cambridge University
Street address Tennis court road
City Cambridge
State/province Cambridgeshire
ZIP/Postal code CB2 1QP
Country United Kingdom
 
Platforms (1)
GPL6102 Illumina human-6 v2.0 expression beadchip
Samples (72)
GSM678949 cervical squamous cell carcinoma cell line_ATCC number CRL_1550 _0hour timepoint_replicate1
GSM678950 cervical squamous cell carcinoma cell line_ATCC number CRL_1550 _0hour timepoint_replicate2
GSM678951 cervical squamous cell carcinoma cell line_ATCC number CRL_1550 _0hour timepoint_replicate3
Relations
BioProject PRJNA138587

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE27480_RAW.tar 5.8 Mb (http)(custom) TAR
GSE27480_non-normalized_data.txt.gz 24.1 Mb (ftp)(http) TXT
Processed data included within Sample table
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