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Series GSE27702 Query DataSets for GSE27702
Status Public on May 29, 2012
Title Highly Pathogenic Avian Influenza Viruses Avoid Effective Inflammatory Response of Human Macrophages
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Macrophages were infected with low (PR8) and high pathogenic influenza viruses (FPV and H5N1). To our surprise a genome-wide comparative systems biology approach revealed that in contrast PR8 infections with HPAIV H5N1 and FPV result in a reduced immune response of human macrophages contradicting a primary role of this cell type for the cytokine storm.
Our data point to a viral strategy of HPAIV to bypass a major amplifier of the initial local inflammatory response thereby hampering antiviral effector mechanisms and facilitating virus spreading and systemic disease.
 
Overall design Macrophages were infected with low (PR8) and high pathogenic influenza viruses (FPV and H5N1)
 
Contributor(s) Friesenhagen J, Roth J, Börgeling Y, Hrincius E, Ludwig S, Viemann D
Citation(s) 22442495
Submission date Mar 07, 2011
Last update date Dec 06, 2018
Contact name Dorothee Viemann
E-mail(s) Viemann.Dorothee@mh-hannover.de
Phone +49-511-532 - 7823
Organization name Hannover Medical School
Department Department of Pediatric Pulmonology, Allergy and Neonatology
Street address Carl-Neuberg-Straße 1
City Hannover
State/province Deutschland
ZIP/Postal code 30625
Country Germany
 
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (12)
GSM686089 control macrophages, biological rep1
GSM686090 control macrophages, biological rep2
GSM686091 control macrophages, biological rep3
Relations
BioProject PRJNA138131

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE27702_RAW.tar 25.1 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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