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Series GSE27858 Query DataSets for GSE27858
Status Public on May 30, 2011
Title The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia
Organism Homo sapiens
Experiment type Expression profiling by array
Summary SPC2996 is a novel locked nucleic acid (LNA) phosphorothioate antisense molecule targeting the mRNA of the Bcl-2 oncoprotein. We investigated the mechanism of action of SPC2996 and the basis for its clinically observed immunostimulatory effects in chronic lymphocytic leukemia (CLL). Patients with relapsed CLL were treated with a maximum of six doses of SPC2996 (0.2-6mg/ kg) in a multicenter phase I trial. Microarray-based transcriptional profiling of circulating CLL cells was carried out before and after the first infusion of SPC2996 in eighteen patients.
We used microarrays to characterize global gene expression changes of circulating CLL cells in response to SPC2996 infusion in 18 patients
Key word : Response to therapeutic agent
Overall design We performed microarray-based gene expression profiling in serial peripheral blood samples from 18 individual CLL patients before and after treatment with SPC2996
Contributor(s) Dürig J, Dührsen U, Klein-Hitpass L, Worm J, Rode Hansen JB, Ørum H, Wissenbach M
Citation(s) 21358717
Submission date Mar 09, 2011
Last update date Mar 25, 2019
Contact name Ludger Klein-Hitpass
Phone +49 201 723 85552
Organization name Institut fuer Zellbiologie
Department Universitaetsklinikum
Lab BioChip Lab
Street address Virchowstr. 173
City Essen
ZIP/Postal code D-45122
Country Germany
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (56)
GSM687644 Patient 401 control
GSM687646 Patient 401 treated 24h
GSM687648 Patient 402 control
BioProject PRJNA137879

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE27858_RAW.tar 288.8 Mb (http)(custom) TAR (of CEL, CHP)
Raw data provided as supplementary file
Processed data included within Sample table
Processed data provided as supplementary file

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