|
| Status |
Public on Jul 01, 2011 |
| Title |
Bmpr2 mutation in murine PMVEC |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Pulmonary arterial hypertension (PAH) is thought to be driven by dysfunction of pulmonary vascular microendothelial cells (PMVEC). Most hereditary PAH is associated with BMPR2 mutations.
However, the physiologic and molecular consequences of expression of BMPR2 mutations in PMVEC are unknown.
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| |
|
| Overall design |
PMVEC were isolated from triple transgenic mice carrying the immortomouse gene, a transactivator, and either control, Bmpr2delx4+ or Bmpr2R899X mutation
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| |
|
| Contributor(s) |
West J, Blackwell T |
| Citation(s) |
21696628 |
| Submission date |
Mar 18, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
James West |
| E-mail(s) |
j.west@vanderbilt.edu
|
| Organization name |
Vanderbilt University
|
| Department |
Medicine
|
| Lab |
Pulmonary
|
| Street address |
4200 E 9TH Ave, Box B133
|
| City |
Nashville |
| State/province |
TN |
| ZIP/Postal code |
37201 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA139753 |
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