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| Status |
Public on Mar 25, 2011 |
| Title |
Novel age related alterations revealed by a comparative kinetic transcriptome analysis of naïve CD4+ and CD8+ T cells from young and old animals. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Define,(a) intrinsic differences and (b) changes occuring upon TCR activation in genetic profiles of naive CD4+ and CD8+ T cells from young and old animals, to identify candidate genes altered in old T cells involved in impairement of immune response in order to restore immune function in the old.
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| Overall design |
Activation dependant time series on sorted naive (CD62Lhi/CD44lo) CD4 and CD8 T cells from young and old animals-Each time point contains RNA pooled from 4 independent sortings
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| Contributor(s) |
Lustgarten J, Pollock K, Mirza N, Hoelzinger DB |
| Citation(s) |
21711441 |
| Submission date |
Mar 24, 2011 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Cheryl E Myers |
| E-mail(s) |
myers.cheryl@mayo.edu
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| Phone |
480-301-4056
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| Organization name |
Mayo Clinic College of Medicine
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| Department |
Immunology
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| Lab |
Cohen
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| Street address |
13400 E Shea Blvd
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| City |
Scottsdale |
| State/province |
AZ |
| ZIP/Postal code |
85259 |
| Country |
USA |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (28)
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| GSM697536 |
ON-CD4+T (CD62Llo/CD44hi), t=0,pool rep1 |
| GSM697537 |
ON-CD4+T (CD62Llo/CD44hi), t=0,pool rep2 |
| GSM697538 |
ON-CD4+T (CD62Llo/CD44hi), t=0,pool rep3 |
| GSM697539 |
ON-CD4+T (CD62Llo/CD44hi), t=4,pool |
| GSM697540 |
ON-CD4+T (CD62Llo/CD44hi), t=12,pool |
| GSM697541 |
ON-CD4+T (CD62Llo/CD44hi), t=24,pool |
| GSM697542 |
ON-CD4+T (CD62Llo/CD44hi), t=72,pool |
| GSM697543 |
YN-CD4+T (CD62Llo/CD44hi), t=0,pool rep 1 |
| GSM697544 |
YN-CD4+T (CD62Llo/CD44hi), t=0,pool rep 2 |
| GSM697545 |
YN-CD4+T (CD62Llo/CD44hi), t=0,pool rep 3 |
| GSM697546 |
YN-CD4+T (CD62Llo/CD44hi), t=4,pool |
| GSM697547 |
YN-CD4+T (CD62Llo/CD44hi), t=12,pool |
| GSM697548 |
YN-CD4+T (CD62Llo/CD44hi), t=24,pool |
| GSM697549 |
YN-CD4+T (CD62Llo/CD44hi), t=72,pool |
| GSM697550 |
ON-CD8+T (CD62Llo/CD44hi), t=0,pool rep1 |
| GSM697551 |
ON-CD8+T (CD62Llo/CD44hi), t=0,pool rep2 |
| GSM697552 |
ON-CD8+T (CD62Llo/CD44hi), t=0,pool rep3 |
| GSM697553 |
ON-CD8+T (CD62Llo/CD44hi), t=4,pool |
| GSM697554 |
ON-CD8+T (CD62Llo/CD44hi), t=12,pool |
| GSM697555 |
ON-CD8+T (CD62Llo/CD44hi), t=24,pool |
| GSM697556 |
ON-CD8+T (CD62Llo/CD44hi), t=72,pool |
| GSM697557 |
YN-CD8+T (CD62Llo/CD44hi), t=0,pool rep1 |
| GSM697558 |
YN-CD8+T (CD62Llo/CD44hi), t=0,pool rep2 |
| GSM697559 |
YN-CD8+T (CD62Llo/CD44hi), t=0,pool rep3 |
| GSM697560 |
YN-CD8+T (CD62Llo/CD44hi), t=4,pool |
| GSM697561 |
YN-CD8+T (CD62Llo/CD44hi), t=12,pool |
| GSM697562 |
YN-CD8+T (CD62Llo/CD44hi), t=24,pool |
| GSM697563 |
YN-CD8+T (CD62Llo/CD44hi), t=72,pool |
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| Relations |
| BioProject |
PRJNA139511 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE28165_RAW.tar |
113.2 Mb |
(http)(custom) |
TAR (of TXT) |
| GSE28165_README.txt |
2.5 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S1 cd8n 2fc t=0.txt.gz |
236.0 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S10 cd4n 2fc 3of4 & not t=0.txt.gz |
112.3 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S11 cd8n k-means cluster analysis.txt.gz |
106.9 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S12 cd4n k-means cluster analysis.txt.gz |
93.9 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S13 cd8n 2fc each time point immune system process.txt.gz |
21.2 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S14 cd4n 2fc each time point immune system process.txt.gz |
23.1 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S15 cd8n 2fc t=0 only.txt.gz |
216.7 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S16 cd4n 2fc t=0 only.txt.gz |
182.2 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S17 cd8n 2fc 4of4 only.txt.gz |
18.1 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S18 cd4n 2fc 4of4 only.txt.gz |
22.4 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S2 cd8n 2fc 2of4.txt.gz |
582.1 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S3 cd8n 2fc t=0 & 2of4.txt.gz |
106.3 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S4 cd8n 2fc 3of4.txt.gz |
164.9 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S5 cd8n 2fc 3of4 & not t=0.txt.gz |
91.7 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S6 cd4n 2fc t=0.txt.gz |
190.0 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S7 cd4n 2fc 2of4.txt.gz |
628.6 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S8 cd4n 2fc t=0 & 2of4.txt.gz |
93.4 Kb |
(ftp)(http) |
TXT |
| GSE28165_Table S9 cd4n 2fc 3of4.txt.gz |
178.1 Kb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
| Processed data are available on Series record |
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