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Series GSE28177 Query DataSets for GSE28177
Status Public on Mar 26, 2011
Title Expression data from HAART interruption in HIV patients
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We evaluated longitudinal changes in viral replication and emergence of viral variants in the context of T cell homeostasis and gene expression in GALT of three HIV-positive patients who initiated HAART during primary HIV infection but opted to interrupt therapy thereafter. Longitudinal viral sequence analysis revealed that a stable proviral reservoir was established in GALT during primary HIV infection that persisted through early HAART and post-therapy interruption. Proviral variants in GALT and peripheral blood mononuclear cells (PBMCs) displayed low levels of genomic diversity at all times. A rapid increase in viral loads with a modest decline of CD4 T cells in peripheral blood was observed, while gut mucosal CD4 T cell loss was severe following HAART interruption. This was accompanied by increased mucosal gene expression regulating interferon (IFN)-mediated antiviral responses and immune activation, a profile similar to those found in HAART-naive HIV-infected patients.
Overall design Gut mucosal responses to HAART interruption were evaluated with Affymetrix arrays
Contributor(s) George MD
Citation(s) 21345945
Submission date Mar 25, 2011
Last update date Mar 25, 2019
Contact name Michael George
Organization name University of California, Davis
Department Medical Microbiology and Immunology
Street address 451 Health Sciences Drive
City Davis
State/province CA
ZIP/Postal code 95616
Country USA
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (6)
GSM697651 uninfected control, biological replicate 1
GSM697652 uninfected control, biological replicate 2
GSM697653 uninfected control, biological replicate 3
BioProject PRJNA139527

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Supplementary file Size Download File type/resource
GSE28177_RAW.tar 26.7 Mb (http)(custom) TAR (of CEL)
Raw data provided as supplementary file
Processed data included within Sample table

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