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| Status |
Public on Aug 31, 2011 |
| Title |
Menthol effect on gene expression profile in malignant prostate cancer cell lines, PC-3 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Menthol, a naturally occurring cooling compound of peppermint oil, induces an anti-proliferative activity in androgen-independent prostate cancer (AIPC). Previously, we found that menthol affects PC-3 cells viability through activating JNK but the mechanism is not fully clear. We thus studied that dysregulated cell cycle progression of PC-3 cells to menthol. We performed microarray experiments to obtain a global view of how menthol affects prostate cancer biology in gene expression profile.
Our study demonstrated that menthol induced G2/M arrest by dysregulating PLK1 in the AICP cell model.
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| Overall design |
Menthol was dissolved in ethanol as a vehicle at 0.1% working concentration and treated in PC-3 cells in triplicate Vehicle-treated PC-3 cells in triplicate were used as control.
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| Contributor(s) |
Kim S, Lee S, Park E, Jung C, Kim T, Cho N, Kim I, So I, Jeon J |
| Citation(s) |
22580005 |
| Submission date |
Mar 29, 2011 |
| Last update date |
Jul 26, 2018 |
| Contact name |
Ju-Hong Jeon |
| E-mail(s) |
jhjeon2@snu.ac.kr
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| Organization name |
Seoul National University College of Medicine
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| Department |
Department of Physiology and Biomedical Sciences
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| Lab |
Smooth muscle lab
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| Street address |
28 Yongon-Dong, Chongno-Gu
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| City |
Seoul |
| State/province |
Seoul |
| ZIP/Postal code |
110-799 |
| Country |
South Korea |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA139587 |
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