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Series GSE28384 Query DataSets for GSE28384
Status Public on May 02, 2012
Title Amorfrutins are selective PPARγ agonists with potent antidiabetic properties
Organisms Homo sapiens; Mus musculus
Experiment type Expression profiling by array
Summary Faced by an alarming incidence of metabolic diseases including obesity and type 2 diabetes worldwide, there is an urgent need for effective strategies for preventing and treating these common diseases. The nuclear receptor PPARγ (peroxisome proliferator-activated receptor gamma) plays a crucial role in metabolism. We isolated the amorfrutins from edible parts of the plants Glychyrrhiza foetida and Amorpha fruticosa, and identified these natural products as a new chemical class to treat insulin resistance and diabetes by selectively activating PPARγ. In contrast to existing synthetic PPARγ drugs, the amorfrutins display unique properties by separating insulin sensitization from unwanted side effects. In obese mouse models, amorfrutin treatment significantly improved important metabolic and inflammatory parameters. In summary, PPARγ activation by selective amorfrutins derived from edible biomaterial is a promising approach to combat metabolic diseases and other diseases in which PPARγ is involved in.
 
Overall design GSM701612-GSM701623: Male DIO C57BL/6 mice (age 18 wks), 3 groups (n=4 each after pooling of 8 samples per group). Mice were fed over 3 wks with high fat diet (HFD) without compound (vehicle), HFD with 4 mg/kg/d rosiglitazone or with 100 mg/kg/d amorfrutin 1. Liver RNA extracted. --> 4 biological replicates, vehicle vs. rosiglitazone or amorfrutin 1

GSM702299-GSM702344: Biological replicates (n = 3-4 each) of human primary adipocytes were treated with the following compounds for 24 hours. 10µM rosiglitazone, 10µM pioglitazone, 30µM telmisartan, 10µM nTZDpa, 30µM amorfrutin 1, 30µM amorfrutin 2, 30µM amorfrutin 3 or 30µM amorfrutin 4 vs. 0.1% DMSO (vehicle)
 
Contributor(s) Weidner C
Citation(s) 22509006
Submission date Apr 05, 2011
Last update date Jan 16, 2019
Contact name Christopher Weidner
E-mail(s) weidner@molgen.mpg.de
Organization name Max Planck-Institute for Molecular Genetics
Department Otto Warburg Laboratory
Lab Sauer
Street address Ihnestraße 63
City Berlin
ZIP/Postal code 14195
Country Germany
 
Platforms (2)
GPL6887 Illumina MouseWG-6 v2.0 expression beadchip
GPL6947 Illumina HumanHT-12 V3.0 expression beadchip
Samples (58)
GSM701612 Liver_vehicle_rep1
GSM701613 Liver_vehicle_rep2
GSM701614 Liver_vehicle_rep3
Relations
BioProject PRJNA139093

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE28384_RAW.tar 22.0 Mb (http)(custom) TAR
GSE28384_non-normalized-2.txt.gz 14.1 Mb (ftp)(http) TXT
GSE28384_non_normalized.txt.gz 3.8 Mb (ftp)(http) TXT
Processed data included within Sample table

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