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| Status |
Public on Apr 01, 2015 |
| Title |
Abrogation of WNT signaling by dominant-negative TCF4 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
To assess cellular changes upon abrogation of the WNT-signaling pathway, we induced expression of a dominant-negative T-cell factor 4 (TCF4). This showed a remarkable overlap with activation of the unfolded protein response (UTR) in the same colon cancer cell line.
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| Overall design |
500,000 cells were plated in a 10 cm2 plate, and the following day, treated for 20 hrs with doxycycline (Dox) or vehicle. Three independent biological replicates per treatment.
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| Contributor(s) |
Heijmans J |
| Citation(s) |
27819675 |
| Submission date |
Apr 07, 2011 |
| Last update date |
Jul 20, 2021 |
| Contact name |
Jarom Heijmans |
| E-mail(s) |
j.heijmans@amc.nl
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| Organization name |
Academic Medical Center
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| Department |
Tytgat Institute for liver and intestinal research
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| Lab |
van den Brink Group
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| Street address |
Meibergdreef 69-71
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| City |
Amsterdam |
| ZIP/Postal code |
1105 BK |
| Country |
Netherlands |
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| Platforms (1) |
| GPL6947 |
Illumina HumanHT-12 V3.0 expression beadchip |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA143227 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE28467_RAW.tar |
6.2 Mb |
(http)(custom) |
TAR |
| Processed data not provided for this record |
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